美国宾夕法尼亚大学博士后职位—神经退行性疾病和癌症生物学

美国宾夕法尼亚大学博士后职位—神经退行性疾病和癌症生物学

Postdoctoral positions in Neurodegeneration & Cancer Biology

Employer

University of Pennsylvania

Location

Philadelphia, Pennsylvania (US)

Salary

$67,000 or higher based on experience

Closing date

21 Aug 2025

The laboratory of Professor Xiaolu Yang at the Perelman School of Medicine, the University of Pennsylvania, is seeking highly motivated postdoctoral researchers to join our dynamic and interdisciplinary team. Our research focuses on fundamental mechanisms underlying neurodegenerative diseases and cancer, with current projects concentrated in two main areas:

1. Protein quality control, aging, and neurodegenerative diseases

We have discovered two novel protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These systems are ATP-independent and uniquely conserved—TRIM in animals and polyD/E in eukaryotes—setting them apart from classical PQC mechanisms. We are exploring their molecular mechanisms, their roles in aging and neurodegenerative diseases (including Alzheimer’s, Parkinson’s, and ALS), and their potential in therapeutic development.

2. Tumor suppression, metabolism, and autophagy

We study the regulation and function of the tumor suppressor p53, focusing on its roles in metabolic pathways essential for biosynthesis and redox balance. Our work explores how p53 functions as both a sensor and regulator of cellular metabolism. We are also identifying metabolic alterations that contribute to tumor initiation and progression. A recent extension of this work examines the role of metabolism and autophagy in stem cells, including embryonic and cancer stem cells.

For more information about our research, please see the following publications and website:

Science 381: eadd6696 (2023); PMID: 37499037

Science Advances 8: eabo0404 (2022); PMID: 35857842

Nature 597: 132-137 (2021); PMID: 34408321

Nature Cell Biology 23: 978–991 (2021); PMID: 34497368

Cell Metabolism 33: 94-109 (2021); PMID: 33159852

Science 369: 397-403 (2020); PMID: 32703873

Cell Reports 33: 108418 (2020); PMID: 33264628

Nature Communications 11: 348 (2020); PMID: 31953436

Nature Communications 10: 1495 (2019); PMID: 30940803

Nature Communications 9: 4683 (2018); PMID: 30409970

Nature Communications 9: 1223 (2018); PMID: 29581427

Cell Reports 18: 3143-3154 (2017); PMID: 28355566

Molecular Cell 55: 15-30 (2014), Cover Article; PMID: 24882209

Nature 493: 689-93 (2013); PMID: 23334421

Nature Cell Biology 15: 991-1000 (2013), Cover Article; PMID: 23811687

Nature Cell Biology 13: 310-316 (2011), Cover Article; PMID: 21336310

Molecular Cell 37: 668-678 (2010), Cover Article; PMID: 20227371

https://www.med.upenn.edu/apps/faculty/index.php/g275/p20138

Qualifications

Applicants should have a strong publication record and relevant experience in areas such as molecular biology, biochemistry, cell biology, neuroscience, cancer biology, metabolism, stem cell biology, and animal models.

Application instructions

To apply, please send a cover letter, curriculum vitae, and contact information for three references to Professor Xiaolu Yang at xyang@pennmedicine.upenn.edu.

About the University of Pennsylvania

The University of Pennsylvania (Penn), a prestigious Ivy League institution, is globally recognized for its excellence in education, research, and innovation. Consistently ranked among the world’s top universities, Penn is home to the Perelman School of Medicine—the oldest and one of the most distinguished medical schools in the United States. The University, including the Perelman School of Medicine, is located on a vibrant urban campus that offers convenient access to a wide array of educational, cultural, and recreational opportunities.

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