美国田纳西州Nashville博后职位DNA复制和DNA损伤反应

The Cortez and Dewar labs are excited to announce newly-available post-doc positions. We seek motivated, enthusiastic post-docs with interests in any of the following areas: replication stress and fork stability; DNA replication termination; cell cycle checkpoint signaling; telomere metabolism; DNA repair; cancer therapies (e.g. PARP inhibitors, topoisomerase poisons); and chromatin duplication. These areas will be explored through a combination of biochemical, genetic, structural, proteomic, and single-molecule approaches across cellular (Cortez), cell-free (Dewar), and reconstituted (Cortez, Dewar) systems.

Drs. Cortez and Dewar have both pioneered novel approaches to study DNA replication in cellular and cell-free systems, respectively (Sirbu et al, 2011, Genes Dev; Dewar et al, 2015, Nature) and exploited these approaches to identify novel regulators of DNA replication and DNA damage responses (Bass et al, 2016, Nat Cell Biol, Dewar et al, 2017, Genes Dev). We will leverage this expertise in a collaborative research initiative to accelerate future discoveries. These studies will take place within the rapidly-expanding Biochemistry department, in association with the Vanderbilt-Ingram Cancer Center. Vanderbilt University is a top international research institute located in Nashville, which is ranked as one of the best cities in the US to live and work. Successful applicants can expect a stimulating research environment at Vanderbilt, which houses numerous labs with interests in genome maintenance.

Applicants should possess a Ph.D in biochemistry, molecular biology, biophysics, or related discipline, and should have one published or forthcoming first author publication. Applications from international scholars are welcome.To apply, or for more information, please email replication.repair@vanderbilt.edu. Applications should include CV and a cover letter describing research preferences. Successful applicants will be appointed in either the Cortez lab, the Dewar lab, or jointly, depending on research preference.