美国芝加哥大学伊利诺伊斯分校分子工程研究所博士后职位招聘

Postdoctoral Scholars

Chicago, Illinois Salary range of $46,000 and $60,000 commensurate with experience IME - University of Chicago

THE UNIVERSITY OF CHICAGO'S INSTITUTE FOR MOLECULAR ENGINEERING has immediate openings at the new Systems Biology and Bioengineering Group with Professor Savas Tay, at the Institute for Molecular Engineering, University of Chicago (http://ime.uchicago.edu/savas_tay/).

We are interested in understanding how immune networks like the NF-kappaB operate under dynamical signaling inputs and how they interact with biological noise at the single-cell level. The following papers describe the current direction of our research program:

• Noise facilitates transcriptional control under dynamic inputs. Kellogg & Tay, Cell 160, 381 (2015)
• Digital signaling decouples activation probability and population heterogeneity. Kellogg, Tian, Lipniacki, Quake, Tay. eLife 4:e08931 (2015)
• Single-cell NF-kB dynamics reveal digital activation and analogue information processing. Tay, et al. Nature 466, 267 (2010)
• High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics. Kellogg, Gómez-Sjöberg, Leyrat, Tay. Nature Protocols, 9(7): 1713 (2014)

Applications from a range of backgrounds including Biology, Physics, Chemistry, Engineering and Computer Science are invited. Required skills include cell culture, basic biochemistry, microscopy, image processing, and programming in MATLAB. Experience with microfluidics, cloning, signaling pathways and stochastic modeling are a plus. Using sophisticated computer controlled experimental setups will be necessary.

We are also developing novel single-cell analysis methods and microfluidic devices to improve measurement functionality, accuracy and throughput. We are particularly interested in multiplexed proteomic, transcriptomic and genomic methods at the single-cell level, with applications to immunity and cell signaling. The following papers describe the biological focus of our research program:

• Noise facilitates transcriptional control under dynamic inputs. Kellogg & Tay, Cell 160, 381 (2015)
• Digital signaling decouples activation probability and population heterogeneity. Kellogg, Tian, Lipniacki, Quake, Tay. eLife 4:e08931 (2015)
• Single-cell NF-kB dynamics reveal digital activation and analogue information processing. Tay, et al. Nature 466, 267 (2010)

Applications from a range of backgrounds including Engineering, Chemistry, and Physics are invited. Required skills include cell culture, basic biochemistry, microscopy, image processing, and programming in MATLAB. Experience with microfluidics, cloning, and modeling are a plus. Constructing and using sophisticated computer controlled experimental setups will be necessary.

Our new laboratory will be located at University of Chicago, and we will be affiliated with the Institute for Molecular Engineering (www.ime.uchicago.edu) and Institute for Genomics and Systems Biology (http://www.igsb.anl.gov/). The researchers recruited through this project will have the opportunity to visit and collaborate with our current group at ETH Zurich in Switzerland (www.microfluidics.ethz.ch) during 2016.

Highly motivated candidates with a strong track record of publications should send an application package with research interests, full CV with experimental and computational skills listed in detail, names and contact information of 3 references to Savas Tay (savas.tay AT gmail.com).