英国比森研究所肿瘤微环境与肿瘤代谢博士后招聘

　　招聘简介：

　　线粒体DNA突变和癌症

　　Payam Gammage博士

　　最初的3年固定期限合同博士后。

　　您是否希望在一个以人员素质为基础的研究机构中发展您的科学事业，以其协作环境而闻名，旨在促进最杰出和最敬业的科学家的发展。许多早期职业研究人员已经做出了这个决定，目前他们中的100多人现在都受益于我们优秀的培训计划。

　　英国癌症研究所Beatson Institute支持对癌症发展的分子机制进行前沿研究，是欧洲领先的研究机构之一。该研究所提供了一个出色的研究环境，以最先进的核心服务和先进技术为基础，特别强调成像，代谢组学和体内模型。

　　英文原文：

　　Mitochondrial DNA mutations and cancer

　　Dr Payam Gammage

　　Initial 3 year fixed term contract.

　　Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists.  Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme.

　　The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, and in vivomodels.

　　Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular:

　　Intrinsic cancer cell vulnerabilities caused by cell growth

　　Interplay between the tumour microenvironment, metastasis and recurrence

　　Biology of early disease, aimed at developing a ‘Precision Prevention’ approach

　　We currently have a vacancy for a Postdoctoral Scientist to explore the role of metabolic dysfunction in cancer. Metabolic dysfunction is intimately linked with cancer initiation and progression and   rewiring of mitochondrial metabolism can greatly benefit the cancer cell, fuelling proliferative and invasive cellular behaviours (Gaude et al., 2018).

　　Mutations of the mitochondrial genome are the most common source of inherited metabolic disease in humans, and that mtDNA mutations cause mitochondrial dysfunction is clear (Gammageet al., 2018a). However the contribution of mutated mtDNA in cancer remains to be addressed.

　　To better understand the nature of metabolic dysfunction in cancer, through use and development of novel genetic tools (Gammage et al., 2018b) in cellular and animal models, we aim to further untangle the role of mitochondrial DNA mutations in human cancer (Gaude et al., 2018).

　　Applicants must have a PhD in a relevant field, be driven by scientific curiosity, and have an excellent publication record in mitochondrial biology and/or cancer biology and metabolism. Experience with in vivo models of cancer and genome engineering techniques will be an advantage.

　　To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of mitochondrial oncogenetics please contact Dr Payam Gammage (p.gammage@beatson.gla.ac.uk)

　　Gammage et al., 2018a, Trends in Genetics. 34:101-110

　　Gammage et al., 2018b, Nature Medicine. 24:1691-1695

　　Gaude et al., 2018, Molecular Cell. 69: 581-593.

　　https://www.researchgate.net/profile/Payam_Gammage

　　At the Cancer Research UK Beatson Institute, we are committed to increasing the number of female scientists at this level and strongly encourage female applicants to apply. We have recently introduced a highly attractive, innovative maternity policy, which includes providing a postdoc with support and funding so that their projects can continue during their maternity leave.

　　All applications must be made via our website at http://www.beatson.gla.ac.uk/careers/postdoctoral-fellows/.

　　Closing date for applications: Friday 29th March 2019