欧洲分子生物学实验所计算生物学、生物信息学、计算机科学或数学博士后招聘

　　招聘简介：

　　合同期限：3年

　　评分：1年津贴

　　我们正在寻找一名博士后研究员，与EMBL-EBI的基因表达团队和Open Targets团队密切合作，该团队位于英国剑桥附近的Wellcome Genome校园。

　　该项目的目标有两个：

　　（1）开发用于鉴定基因表达特征并将其与疾病表型相关联的荟萃分析方法。

　　（2）使用表达数据作为中间表型，研究罕见疾病与具有相似表型的复杂疾病之间的联系。

　　开放目标项目是惠康信托桑格研究所，欧洲生物信息学研究所，葛兰素史克，Biogen和武田的团队通过一项公私合作计划，旨在为治疗目标的有效性提供证据，并致力于分享其目标。公开与科学界的数据。

　　职位需求

　　您最初将与我们在开放目标中的制药合作者密切合作，以确定阿尔茨海默病进展表型的基因特征，但该方法也将扩展到其他疾病。您将分析数据集并开发签名派生的新方法以及特定疾病的应用。这将解决我们如何诊断疾病并确定其原因和可能的治疗方法的挑战性问题。您的方法将直接用于Expression Atlas的数据生成管道，这是EBI的核心开放资源之一。

　　该图谱提供了一种有力的途径，可以找到跨物种和生物条件的基因和蛋白质表达信息，例如不同的组织，细胞类型，发育阶段和疾病等。现在有来自30多种不同生物的3,000多个实验（微阵列和RNA测序）的表达数据。对人类疾病数据的分析直接输入开放目标项目的目标验证平台，该项目将通过提供表达疾病签名为该平台做出贡献。

　　英文原文：

　　Contract Duration: 3 years

　　Grading: Yr 1 stipend

　　We are seeking to recruit a Postdoctoral Fellow for a position in the Thornton Research Group, working closely with the Gene Expression Team at EMBL-EBI and the Open Targets team, co-located on the Wellcome Genome Campus, near Cambridge, UK.

　　The aims of the project are twofold:

　　(1) To develop meta-analysis methods for identifying gene expression signatures and linking these to disease phenotypes.

　　(2) To investigate links between rare diseases and complex diseases with similar phenotypes, using expression data as an intermediate phenotype.

　　The Open Targets project is a collaborative effort involving teams in the Wellcome Trust Sanger Institute, the European Bioinformatics Institute, GlaxoSmithKline, Biogen and Takeda through a public-private initiative aiming at generating evidence on the validity of therapeutic targets, and is committed to sharing its data openly with the scientific community.

　　Your role

　　You will work closely with our pharma collaborators in Open Targets initially to identify gene signatures for Alzheimer's disease progression phenotypes, but the approach will also be extended to other diseases. You will analyse datasets and develop new methods for signature derivation and also applications to specific diseases. This will address the challenging problem of how we diagnose diseases and identify their causes and possible therapeutics. Your methods will directly contribute to the data production pipelines of the Expression Atlas, which is one of EBI’s core open resources.

　　The atlas provides a powerful route to find information about gene and protein expression across species and biological conditions, such as different tissues, cell types, developmental stages and diseases among others. There are now expression data for more than 3,000 experiments (microarray and RNA-sequencing) from over 30 different organisms. Analyses on human disease data are directly fed into the Target Validation Platform of the Open Targets project and this project will contribute to this platform by providing expression disease signatures.

　　You have

　　PhD degree in Computational Biology, Bioinformatics, Computer Science or Mathematics

　　Bioinformatics data analysis methods development

　　Working in a unix-based environment and high performance computing cluster environment

　　Gene expression data analysis (NGS and microarrays)

　　Strong technical, interpersonal and communication skills are key to this position. The scientists involved come from many different disciplines including biology, computational sciences and statisticians.

　　You might also have

　　Background in statistical methods development

　　Background in working with data from age-related neurodegenerative diseases

　　Why join us

　　At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states.

　　What else do I need to know

　　To apply please submit a covering letter and CV through our online system.