美国冷泉港实验室招收博士后—长链非编码RNAs (lncRNAs)在多能性及分化中的作用

美国冷泉港实验室招收博士后—长链非编码RNAs (lncRNAs)在多能性及分化中的作用

Postdoctoral Fellow – Spector Lab

Cold Spring Harbor Laboratory

Date Posted: Posted on 9 June 2025

Location: United States (US)

Salary: $74,300 - $74,300

A postdoctoral position is currently available, in the laboratory of Dr. David L. Spector at Cold Spring Harbor Laboratory, for a highly motivated outstanding individual to study Long Non-Coding RNAs (lncRNAs) in Pluripotency and Differentiation. LncRNAs are an exciting class of of RNA molecules among which very few have thus far been functionally characterized in depth. We performed an RNA-seq screen in mouse embryonic stem cells and neural progenitor cells and identified differentially expressed lncRNAs. The proposed studies will build upon these findings and use innovative methods to interrogate the functional role of specific lncRNAs in pluripotency, differentiation, and disease.

Selected publications:

Sunwoo,H., Dinger,M.E., Wilusz, J.E., Amaral, P.P., Mattick, J.S. and Spector, D.L.  2009. MEN e/b nuclear retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Research 19, 347-359.

Bergmann, J.H. and Spector, D.L. 2014. Long non-coding RNAs: modulators of nuclear structure and function. Current Opinion in Cell Biology 26, 10-18.

Hazra, R., Brine, L., Garcia, L., Benz, B., Chirathivat, N., Shen, M.M., Wilkinson, J.E., Lyons, S.K., and Spector, D.L. 2022. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.  Dev. Cell 57, 2450-2468.

Hazra, R. and Spector, D.L. 2022. Simultaneous visualization of long non-coding RNAs and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy. Front. Cell Dev. Biol. 10:986261. doi: 10.3389/fcell.2022.986261.

Position Requirements

Candidates must have (or soon receive) a PhD degree. Experience in mouse embryonic stem cell culturing and differentiation, genomic analysis, molecular biology, CRISPR-based approaches, and mouse models is a plus.

Environment

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program. We believe that science is for everyone and our researchers have a wide variety of backgrounds.

Compensation & Benefits

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs.  The salary for this role is $74,300.00 per annum. The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).

CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status. VEVRAA Federal Contractor

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