美国得克萨斯大学休斯顿健康科学中心博士后---神经炎症与神经变性中的缺氧

美国得克萨斯大学休斯顿健康科学中心博士后---神经炎症与神经变性中的缺氧

得克萨斯大学休斯顿健康科学中心（University of Texas Health Science Center at Houston）成立于1972年，由牙科分校、生物医学研究所、医学院、公共卫生学院、护理学院、健康资讯科学学院、哈里斯郡精神中心和布朗基础学院分子医学中心合并而成，主要目的是预防人类疾病。

Hypoxia in Neuroinflammation and Neurodegeneration

University of Texas Health Science Center at Houston

Job Description

The Center for Perioperative Medicine at the Department of Anesthesiology, McGovern Medical School of the University of Texas Health Science Center at Houston is offering a federally funded, fully supported postdoctoral position. We seek an outstanding scientist to join our team and research the hypoxia response associated with Alzheimer's disease (AD).

AD is a leading health and economic burden in the US, and neuroinflammation is recognized as a major contributor to the disease's complex etiology. However, the molecular modifiers for the neuroinflammatory response remain incompletely understood. Oxygen deprivation triggers a rapid adaptive response called hypoxia that stimulates anaerobic metabolism and angiogenesis to protect the host. A molecular understanding of how hypoxia modifies AD pathogenesis, specifically neuroinflammation, is currently lacking.

The focus of the project is to delineate the hypoxia response associated with major AD pathologies in mouse models, with the aim of illuminating the function of hypoxia-inducible factors (HIFs) in neuroinflammation and neurodegeneration. HIFs are the master regulators of the hypoxia response, and their role in AD pathogenesis is poorly understood.

This project will be led jointly by two established principal investigators, Dr. Wei Cao and Dr. Holger Eltzschig. Dr. Cao's laboratory studies the molecular underpinning of inflammatory events associated with AD-related conditions, while Dr. Eltzschig's laboratory investigates endogenous adaptive pathways that are under the control of HIFs in various diseases.

We encourage motivated candidates with in-depth training and knowledge in neuroscience, molecular biology, and/or immunology to apply. Previous experience with biochemistry, confocal microscopy, and/or in vivo disease modeling is a plus.

Job Duties

• Initiate, conduct, and lead research projects based on sound and innovative scientific hypotheses.

• Develop technical expertise in areas such as genetic animal models, recombinant viral vectors, confocal imaging, molecular biology, and multiomics analysis.

• Plan, direct, and conduct specialized and advanced research experiments; establish new research protocols and procedures; and evaluate and analyze data.

• Summarize the research findings and write and publish the results in research journals.

• Responsible for laboratory operations in a team environment.

• Participate in educational events such as journal clubs and research presentations in both formal and informal settings on a regular basis.

• Collaborate with investigators outside the lab and main effective communication

Application Requirements:

• Education: MD or Ph.D. in Basic Science, Health Science,

• No experience required

How to apply

If you are interested in this exciting opportunity, please submit your CV, a cover letter outlining your research experience and interests, and contact information for three references to Dr. Wei Cao (wei.cao@uth.tmc.edu ) and Dr. Holger Eltzschig (holger.eltzschig@uth.tmc.edu ).

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