英国邓迪大学生物科学博士后科学家

英国邓迪大学生物科学博士后科学家

邓迪大学（University of Dundee，简称UoD），始创立于1881年，是一座坐落于英国邓迪市的世界一流的著名研究型大学。2021泰晤士高等教育世界大学排名第201-250位，科研水平在欧洲以及全球有着极高的声誉。连续六年（2010-2016）苏格兰大学满意度第一。2021年英国《卫报》大学排名第19位。邓迪大学在许多领域具有世界一流水平，其中最为突出的学科领域包括：生命科学、医学、商学、教育学、金融、会计、法律、建筑、艺术与设计、材料科学工程。其中在生命科学、艺术设计、教育学领域居全球Top100。邓迪大学的教学质量和科研水平均名列英国前茅，2017-2020年由英国皇家教育部颁布的TEF评选中，被评为“金奖大学”，2014英国女王年度奖章-高等教育杰出贡献奖。

Postdoctoral Scientist

University of Dundee - Biological Sciences

Location:Liverpool

Salary:£34,308 to £42,155

Hours:Full Time

Contract Type:Fixed-Term/Contract

Placed On:17th January 2023

Closes:16th February 2023

The Kulathu Lab at the MRC PPU, University of Dundee, Scotland is looking to hire a postdoctoral researcher with expertise in cell biology and/or biochemistry to dissect how distinct branched heterotypic signals are formed in cells in response to stress and serve to trigger stress response pathways.

Our lab studies how posttranslational modification of proteins with monoubiquitin or different polyubiquitin chains alters protein function to signal distinct responses in cells. A new type of ubiquitin signal has been discovered recently that contains branched ubiquitin structures. These branched heterotypic ubiquitin signals are dynamically made in cells and play important roles in maintaining cellular homeostasis. Mechanistically, the functions of these branched chains have not been elucidated because of the complex nature of these modifications and the lack of ways to study them. You will employ a highly multidisciplinary approach, with techniques including quantitative proteomics, CRISPR/Cas9 gene editing combined with biochemical and c ell biology approaches to dissect signalling pathways and single cell analyses to address exciting questions about the mechanisms and functions of branched ubiquitin chains in cellular stress responses.

The project is funded by an ERC Consolidator grant awarded recently to the lab, and will build on tools and methods the lab has recently developed to study branched ubiquitin. The position is available for 3 years in the first instance. The candidate will join a stimulating, diverse and collaborative research environment. Strong mentorship will be provided to help candidates achieve their career goals.

Your priorities will include:

Undertaking research aimed at understanding the molecular mechanisms of signalling by ubiquitin and ubiquitin-like modifiers in maintaining cellular homeostasis.

Project development and implementation, including experimental design; identification and development of a broad range of techniques necessary to achieve the research.

Working collaboratively, coordinating with collaborators, and assisting with the training of PhD students and other lab members

Presenting scientific work at internal seminars and at external meetings.

Contributing to the preparation of research for publication

Who we’re looking for:

Successful candidates will have a strong background in biochemistry and/or cell biology and a track record in conducting excellent research. You should be creative and ambitious, enthusiastic to study complex biological questions, and have excellent communication skills.

Candidates are expected to have expertise in:

Biochemistry, Cell biology and/or proteomics

Experience in studying cell signalling, posttranslational modifications, protein quality control, protein degradation or DNA damage pathways

Experience with microscopy would be advantageous

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a Ph.D. An appointment may be considered if you are shortly expected to be awarded a Ph.D. In this case, the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 25 – 28).

Additional Information

We are one of the UK’s leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University

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