德国癌症研究中心博士后—神经病理学-单细胞和空间测序

德国癌症研究中心博士后—神经病理学-单细胞和空间测序

德国癌症研究中心 dkfz.Deutsches Krebsforschungszentrum（德国癌症研究中心，dkfz）成立于1964年，坐落于巴登符腾堡州的德国教育和科研中心之一的海德堡大学内，与著名的海德堡城堡隔内卡河遥遥相望。

Postdoctoral Scientist in Neuropathology for Single-cell and Spatial Sequencing

DeutschesKrebsforschungszentrum

Position: Postdoctoral Scientist in Neuropathology for Single-cell and Spatial Sequencing

Department: Clinical Cooperation Unit Neuropathology

Code number: 2022-0481

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The group of Prof. Dr. Felix Sahm at the Clinical Cooperation Unit (CCU) Neuropathology is looking for a postdoctoral researcher to lead a project group that translates single-cell and spatial profiling into personalized oncology.

Job description:

The successful candidate will devise novel molecular approaches that disrupt current technical boundaries between “traditional” and “modern” tissue profiling: Molecular and morphological characterization will converge on spatial profiling with single-cell resolution, yet not limited to one layer of biological readout but including epigenetic regulation, mutations, copy- number-alterations, gene and protein expression in parallel. The integration of multi-layered data in a spatial context will enable to correlate the molecular findings with histopathological criteria of classification and grading, supported by our database of >50,000 digitalized histology sections. The study will be conducted in close collaboration with our partners employing AI algorithms for tissue profiling.

The successful candidate will work in our interdisciplinary team of physicians, biologists, and informaticians to bridge the gap between high- throughput molecular analysis and routinely used histopathology in diagnostic applications. The CCU Neuropathology and our group are positioned at the interface of biomarker research, clinical diagnostics and individualized therapy trials, an excellent foundation for this endeavor.

This endeavor will benefit from the thriving environment at the DKFZ and Heidelberg Life Science Campus, including a DFG-funded comprehensive research center (SFB) in neurooncology, interaction with our international collaborators, and the cutting-edge-technology with short- and long-read- sequencing, library preparation automation, single-cell microfluidics and mass spectrometry on-site.

The project conditions are optimal for a candidate who wants to grow into an independent role and subsequently apply for group leader positions.

Selected publications: 1. Maas, S.L.N., et al., Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated. J ClinOncol, 2021. 39(34): p. 3839-3852. 2. Zheng, T., et al., Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive SupratentorialEpendymomas. Cancer Discov, 2021. 11(9): p. 2230-2247. 3. Sahm, F., et al., DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol, 2017. 18(5): p. 682-694. 4. Patel, A., et al., Rapid-CNS(2): rapid comprehensive adaptive nanopore- sequencing of CNS tumors, a proof-of-concept study. ActaNeuropathol, 2022. 143(5): p. 609-612. 5. Dogan, H., et al., Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas. ActaNeuropathol, 2022. 144(4): p. 799-802. 6. Capper, D., et al., DNA methylation-based classification of central nervous system tumours. Nature, 2018. 555(7697): p. 469-474.

Requirements:

Master's degree and PhD degree in any relevant field of life sciences, preferably related to genomics, molecular biology, pathology, or oncology

Experience with next-generation sequencing technology and data interpretation

Excellent written and oral communication skills in English

Ability and willingness to supervise students and staff

We offer:

Interesting, versatile workplace

International, attractive working environment

Campus with modern state-of-the-art infrastructure

Salary according to TV-L including social benefits

Possibility to work part-time

Flexible working hours

Comprehensive further training program

Access to the DKFZ International Postdoc Program

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years.

The position can in principle be part-time.

Application deadline: 19.01.2023

Contact:

Dr. Felix Sahm Phone +49 6221/56-37886

Please note that we do not accept applications submitted via email.

准备申请国外博士后的各位老师注意了！知识人网（www.zsr.cc）小编每周定时更新最新的国内外博士后招聘信息以及访问学者、博士后资讯，感谢大家的关注！