法国脑科研究所博士后职位

法国脑科研究所博士后职位

Post-doctoral position - Cerebral cavernous malformations - Paris

Paris Brain Institute

The field of brain tumors has recently become closer to the field of vascular malformations with the recent discovery of oncogenic mutations in brain arteriovenous and cavernous malformations. I am a neurosurgeon at Pitié-Salpêtrière hospital in Paris, France and researcher at Paris Brain Institute working in the team « Genetics and development of brain tumors » and looking for a post-doctoral fellow to conduct a translational project on brain cavernous malformations, following my recent publication in the New England Journal of Medicine. The post-doctoral fellow would be the main person attached to the project, requiring a high level of scientific skills, autonomy, and a capacity to rapidly build collaborations inside the Institute. This project requires an expertise in genetically engineered mouse models and somatic mutations in human disease.

LENGTH

• 36 months

MAIN TASKS

• Creation and characterization of new genetically engineered mouse models of brain cavernous malformations

• Pre-clinical study of targeted drugs in mouse models of brain cavernous malformations

• Single cell sequencing of human cavernomas and theranostic machine learning analysis of brain MRIs

PROFILE

SCIENTIFIC SKILLS

• Basic methods in animal studies (anesthesia, stereotactic surgery, treatment)

• Basic methods of molecular biology (multi-omics, ddPCR) and cell culture

• Statistics (with R software)

KNOWLEDGE

• PhD Neurosciences

• Extensive knowledge of genetically engineered mouse models

• Extensive knowledge of multi-omics and single cell analysis

• Knowledge of immunohistochemistry, microscopy, image analysis

• Fluency in spoken and written English

SOCIAL SKILLS

• Autonomy, sense of initiative, good interpersonal skills

• Capacity to work in an interdisciplinary (researchers, physicians) and international environment

CONTACT

Dr Matthieu PEYRE, MCU-PH, M.D., Ph.D.

Neurosurgery Department – Hôpital Pitié-Salpêtrière

Genetics and Development of Brain Tumors – Paris Brain Institute

47-83, boulevard de l’Hôpital – 75651 Paris cedex 13

Tel. 00-33-1 42 16 31 03

Mail. matthieu.peyre@aphp.fr

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