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美国哥伦比亚大学欧文医学中心博士后职位
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美国哥伦比亚大学欧文医学中心博士后职位

Postdoctoral Research Scientist

Columbia University Medical Center (CUMC), CU

THE OPPORTUNITY

An immediate Postdoctoral Research Scientist position is available in the laboratory of Dr. Sebastian A. Riquelme at Columbia University Irving Medical Center in New York. The mission of Dr. Riquelme lab is to understand how metabolism determines the outcome of infectious diseases. We apply cutting-edge OMICs technologies, such as single-cell RNA-Seq, dual RNA-Seq, metabolomics, genome sequencing and proteomics to dissect host-pathogen crosstalk, putting emphasis on the immunometabolic pathways exploited by opportunists to thrive in the human lung. Our group studies Gram-negative and Gram-positive bacterial diseases, using both laboratory strains and clinical isolates obtained from the lung of acutely and chronically infected subjects. Our work is translational, as we employ both in vitro and in vivo models of infection to answer clinically relevant questions.

This opportunity to join the Department of Pediatrics at the Vagelos College of Physicians and Surgeons at the rank of Postdoctoral Research Scientist is an exciting one. Columbia University Irving Medical Center is one of the nation’s foremost academic health science centers. The Department of Pediatrics at Columbia University Irving Medical Center is the top in comparison with other pediatrics department in the NY region in NIH research funding. Our institution represents the essence of New York, being a large, diverse, and multicultural community that encourages collaborative and innovative work. We are in close contact with many national and foreign laboratories with whom we hold interactive meetings that enrich even more the excellent academic environment found in our facilities. Postdoctoral scientists at Columbia University participate in several national and international conferences, which provides them with a unique opportunity to present their research, engage in collaborative work with peers, and gain valuable networking experience.

KEY RESPONSIBILITIES

Generate both bacterial mutants and in vivo models of infection to advance the discovery of novel mechanisms of pathogenesis

Work independently, in an organized fashion, and in collaboration with the rest of lab members

Conduct scientific research in a responsible manner following the institutional ethical guidelines

Design and execute experiments in a timely manner, as well as analyze and discuss the findings obtained in laboratory meetings. Ensure laboratory notebook is well organized and legible

Troubleshoot experiments when necessary, using reasonable approaches

Engage in scientific support to graduate students, summer scholars, and laboratory personnel when required

Actively write scientific manuscripts and funding applications

Present research data in national and international scientific meetings

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

Applicants interested in this position should hold a recent PhD degree in Immunology, Microbiology, Cell Biology or related area. The selected candidate will study how specific metabolic pathways in both host and pathogen influence the development of pneumonia. The candidate will have a solid foundation in immunometabolism, with special emphasis in the metabolic pathways that govern macrophage activation. Applicants should have advanced training in both cell culture and bacterial culture. Technical expertise required includes Seahorse assays, multicolor flow cytometry, qRT-PCR, ELISA, RNA-Seq and western blot. Experience with in vivo models of pneumonia and generation of mutant bacteria is advantageous. Training in bioinformatic analysis of big datasets, such as single-cell RNA-Seq transcriptomics, genomics, and metabolomics is valuable, but not essential.

COMPENSATION

Compensation is competitive and commensurate with both experience, achievement, and standards recommended by NIH.

COMMITMENT OF DIVERSITY

Columbia University is an Equal Opportunity/Affirmative Action Employer and Educator. The University is dedicated to the goal of building a culturally diverse and pluralistic faculty and staff committed to teaching and working in a diverse environment, and strongly encourages applications from women, minorities, individuals with disabilities, and veterans. Columbia University welcomes applications from individuals who may have had nontraditional career paths, or who may have taken time off for family reasons (e.g. children, caring for disabled or elderly family), or who have achieved excellence in careers outside of academia (e.g., in professional or industry service). The University is responsive to the needs of dual career couples and is committed to supporting the work-life balance of its faculty. We are interested in candidates who have a record of success advising and mentoring individuals from groups underrepresented in higher education and is particularly interested in candidates who have research interests in subjects that will contribute to the understanding of diversity and equal opportunity.

HOW TO APPLY

To apply for this position, please send a cover letter, Curriculum Vitae (CV), and three references to Dr. Sebastian A. Riquelme at sr3302@cumc.columbia.edu or visit https://apply.interfolio.com/113603.

PUBLICATIONS RELATED TO THIS POSITION

Tomlinson et al, Nature Communications, 2021.

Riquelme et al, Cell Metabolism, 2020.

Riquelme et al, Science Translational Medicine, 2019.

Riquelme et al, Immunity, 2017.

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