法国IFM研究所神经发育与癫痫研究博士后

法国IFM研究所神经发育与癫痫研究博士后

Postdoctoral Researcher In Neurodevelopment And Epilepsy

Organisation/Company: Institut du Fer à Moulin

Research Field: Neurosciences › Neurobiology Neurosciences › Neurophysiology

Researcher Profile: First Stage Researcher (R1)

Application Deadline: 31/03/2022 18:00 - Europe/Brussels

Location: France › Paris

Type Of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 03/04/2022

Eu Research Framework Programme: HE

Reference Number: JTC2021

A fully-funded, 36-month postdoc position is open from April 2022 in the Poncer lab at the Institut du Fer à Moulin, Paris, to study the anomalous persistence of transient cortical neurons in epilepsy. This collaborative project funded by ERANET Neuron gathers a consortium of 5 leading European groups in the fields of neurodevelopment and epilepsy (Pierani and Poncer in Paris, de la Prida in Madrid, Luhmann in Mainz, and Aronica in Amsterdam).

Programmed cell death of transient neurons, in particular Cajal-Retzius neurons (CRs), is emerging as a key player in cortical development. Anomalous postnatal persistence of CRs is detected in various forms of epilepsy and schizophrenia. Our project aims to explore how persistent CRs contribute to anomalous activities underlying these neurodevelopmental disorders. Combining mouse genetics, viral-based tracing methods, and in vitro electrophysiology, we will first test whether and how persistent CRs of diverse origins are synaptically integrated into cortical networks. Next, we will explore how the persistence of distinct CRs perturbs the synaptic and intrinsic properties of cortical neurons. Finally, we will unravel the molecular mechanisms underlying programmed cell death of various CR subtypes and their alteration in the pathology, with specific emphasis on neuronal chloride transport.

The successful candidate will join a dynamic, multidisciplinary research team focused on the molecular and cellular determinants of epileptic networks, with expertise ranging from single-molecule tracking approaches to in vitro and in vivo electrophysiology. He/she will also participate in consortium activities, including annual scientific meetings, progress reports, and interaction with patient organizations for outreach activities.

Candidates should hold a Ph.D. in Neuroscience and have solid experience with in vitro slice electrophysiology. Prior experience with stereotaxic injections and mouse models is preferred. Excellent teamwork and English communication skills are required.

For application, please send a CV, a brief description of research experience and interests, and the names and email addresses of two references to jean- christophe.poncer@inserm.fr

Benefits

IFM is committed to providing a stimulating and collaborative work environment based on equity and inclusion, with access to state-of-the-art technological platforms and services.

We offer an initial 3-year contract. The sucessfull candidate will receive salary as per Inserm standards, depending on research experience, including medical coverage, public transportation and family allowances (if applicable).

Eligibility criteria

Candidates should hold a PhD or equivalent degree in Life Sciences at the time of employment, preferably in Neurosciences, a solid background in Neurosciences and expertise in cellular electrophysiology

Selection process

Candidates should send a CV, motivation letter and the names and email addresses of at least two references.

On-line interviews of selected candidates will be organized in early 2022.

Short-listed candidates will be invited for an on-site visit.

Required Research Experiences

RESEARCH FIELD

Neurosciences › Neurophysiology

YEARS OF RESEARCH EXPERIENCE

1 - 4

Offer Requirements

REQUIRED EDUCATION LEVEL

Neurosciences: PhD or equivalent

Biological sciences: PhD or equivalent

Skills/Qualifications

Required :

Excellent teamwork skills

Communication in English

Autonomy

Self-motivation

Organization

Specific Requirements

Required :

In vitro slice electrophysiology (patch clamp)

Animal handling, mouse colony follow-up

Preferred :

Stereotaxic injections

Contact Information

Organisation/Company: Institut du Fer à Moulin

Department: INSERM U1270

Organisation Type: Public Research Institution

Website: https:// ifm-institute.fr

E-Mail: jean-christophe.poncer@inserm.fr

Country: France

City: Paris

Postal Code: 75005

Street: 8 rue des Fosses Saint Marcel