英国伯明翰大学博士后职位---免疫学与免疫疗法

英国伯明翰大学博士后职位---免疫学与免疫疗法

Research Fellow - Institute of Immunology and Immunotherapy -98830 - Grade 7

University of Birmingham

Description

Background

We seek to appoint a highly motivated individual to join an internationally recognised research group in the College of Medical and Dental Sciences' Institute for Immunology and Immunotherapy. The post holder will be based in the research group of Professor Ben Willcox.

The post holder will join the research team of Professor Willcox funded by a Wellcome Trust Collaborative Award in Science, entitled ‘Unconventional dynamics: turnover, structure and maintenance of the γδ T cell population in humans.' The post-holder will lead Willcox group efforts on this Collaborator award, to help generate a quantitative understanding of the dynamics of human γδ T cell populations. They will working with our partner teams led by Professor Becca Asquith (Imperial College London) and Professor Derek Macallan (St George's, University of London), collectively employing an interdisciplinary approach that includes non-invasive labelling technologies (pioneered by Prof Macallan), clonotypic, phenoytypic and functional assays of γδ T cells and comparator populations (a focus for the Willcox group) and mathematical modelling (led by Prof Asquith's team). The post-holder's efforts will focus significantly on γδ TCR sequencing, immunophenotyping, and telomere length and thymic recombination excision circle (TREC) analysis, alongside functional assays. The collaborative team will integrate information gained on the dynamics of both innate-like and adaptive-like human γδ T cell populations and how these compare with established classical adaptive and innate-like αβ T cell populations. We will synthesise the information obtained to generate a quantitative, mechanistic model of how distinct γδ T cell subsets are controlled in normal immune physiology relative to other immune compartments, and how they change with age.

Summary of Role

  Work within specified research grants and projects and contribute to writing bids

  Analyse and interpret research findings and results

  Contribute to high quality publications and data supporting external funding applications

  Contribute to workstreams linking with γδ T cell repertoire studies and ligand interactions

Main Duties / Responsibilities The responsibilities may include some but not all of the responsibilities outlined below.

  Develop research objectives and proposals for own or joint research, with assistance of a mentor if required

  Contribute to writing bids for research funding

  Analyse and interpret data

  Apply knowledge in a way which develops new intellectual understanding

  Disseminate research findings for publication, research seminars etc

  Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline

  Contribute to developing new models, techniques and methods

  Undertake management/administration arising from research

  Contribute to Departmental/School research-related activities and research-related administration

  Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader

  Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews

  Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters

  Provide guidance, as required, to support staff and any students who may be assisting with the research

  Deal with problems that may affect the achievement of research objectives and deadlines

  Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.

Person Specification

  First degree in area of specialism and a PhD and/or post-doctoral experience in immunology

  High level analytical capability

  Ability to communicate complex information clearly

  Fluency in relevant models, techniques or methods and ability to contribute to developing new ones, including specialist knowledge of flow cytometry, cell sorting, PCR and other molecular techniques

  Ability to assess resource requirements and use resources effectively

  Understanding of and ability to contribute to broader management/administration processes

  Contribute to the planning and organising of the research programme and/or specific research project

  Co-ordinate own work with others to avoid conflict or duplication of effort

  Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly

Informal enquires to Ben Wilcox (b.wilcox@bham.ac.uk)