英国牛津大学博士后职位---内聚素对DNA捕获和环挤出的机理过程研究

英国牛津大学博士后职位---内聚素对DNA捕获和环挤出的机理过程研究

Postdoctoral Research Associate in Mechanistic Processes of DNA Entrapment and Loop Extrusion by Cohesin

University Of Oxford

Description

Postdoctoral Research Associate in Mechanistic Processes of DNA Entrapment and Loop Extrusion by Cohesin

Department of Biochemistry, South Parks Road, Oxford Grade 7: £33,309 - £40,927 per annum

We are seeking to appoint a Postdoctoral Research Associate to join the Chromosome Biology research group lead by Professor Kim Nasmyth. In particular, we are looking for someone interested in developing novel in vitro techniques to probe the mechanistic details surrounding the processes of DNA entrapment and loop extrusion by cohesin.

Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in a relevant subject; and have experience in the relevant field of chromosome biology. You should have laboratory experience in core molecular and biochemical techniques, especially with protein engineering, protein expression using bacteria and insect cell systems, protein purification using AKTA systems and other protein analysis techniques, together with experience in protein crosslinking assays and in-vitro ATP hydrolysis measurement techniques. Experience with quantitative image analysis, negative stain electron microscopy is essential, along with skills in structural biology including x-ray crystallography and SAXs, as is having a good publication record in peer-reviewed journals.

This full-time, fixed-term post is funded by Cancer Research UK for up to 1 year in the first instance and is based at The Department of Biochemistry, South Parks Road, Oxford.

This position is graded on the University's grade 7 scale. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

To apply for this role and for further details including the job description and selection criteria, please see the document below. You will be required to upload a supporting statement and CV as part of your application.

The closing date for applications is 12.00 noon on Tuesday 7th December 2021, with interviews for shortlisted candidates to be held as soon as possible thereafter.