美国圣路易斯华盛顿大学基因表达调控与RNA生物学博士后

美国圣路易斯华盛顿大学基因表达调控与RNA生物学博士后

Postdoctoral Fellow in Gene Expression Regulation and RNA Biology

Washington University in St. Louis (WUSTL)

A postdoctoral research position is available for NIH-funded research in the lab of Dr. Sergej Djuranovic at the Department of Cell Biology and Physiology in Washington University, School of Medicine. Djuranovic Lab is primarily interested in understanding the mechanisms of post-transcriptional gene regulation. We focus on RNA-binding proteins (RBPs), ribonucleoprotein (RNP complexes), mRNA and protein sequence motifs, all of which control translational efficiency of their target mRNAs or are involved in general RNA and protein metabolism. We are taking advantage of biochemical, molecular/cellular biology, computational, and genetics approaches to study mechanisms by which microRNAs, RNA-binding proteins, and components of mRNA surveillance mechanisms regulate gene expression in health and disease states. We focus on topics such as cell differentiation, cancer, neurodegeneration and malaria.

Examples of the recent publication from the lab include:

-         https://www.science.org/doi/10.1126/sciadv.1500154

Arthur L, Pavlovic-Djuranovic S, Smith-Koutmou K, Green R, Szczesny P, Djuranovic S. Translational control by lysine-encoding A-rich sequences. Sci Adv. 2015 Jul;1(6):e1500154. doi: 10.1126/sciadv.1500154. PMID: 26322332; PMCID: PMC4552401.

-         https://www.nature.com/articles/s41467-017-02745-0

Cottrell KA, Chaudhari HG, Cohen BA, Djuranovic S. PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs. Nat Commun. 2018 Jan 19;9(1):301. doi: 10.1038/s41467-017-02745-0. PMID: 29352242; PMCID: PMC5775260.

-         https://www.nature.com/articles/s41467-019-13810-1

Verma M, Choi J, Cottrell KA, Lavagnino Z, Thomas EN, Pavlovic-Djuranovic S, Szczesny P, Piston DW, Zaher HS, Puglisi JD, Djuranovic S. A short translational ramp determines the efficiency of protein synthesis. Nat Commun. 2019 Dec 18;10(1):5774. doi: 10.1038/s41467-019-13810-1. PMID: 31852903; PMCID: PMC6920384.

- https://elifesciences.org/articles/57799v1

Pavlovic Djuranovic S, Erath J, Andrews RJ, Bayguinov PO, Chung JJ, Chalker DL, Fitzpatrick JA, Moss WN, Szczesny P, Djuranovic S. Plasmodium falciparum translational machinery condones polyadenosine repeats. Elife. 2020 May 29;9:e57799. doi: 10.7554/eLife.57799. PMID: 32469313; PMCID: PMC7295572.

Applicants with demonstrated expertise in RNA and protein biology, protein and nucleic acid biochemistry, structural biology, genetics or genomics are encouraged. Applicants must hold a Ph.D. degree, a productive track record, and high writing and communication skills. The successful applicant will have a unique opportunity to work in close collaboration within the Departments of Cell Biology and Physiology, Biology, Biochemistry, Genetics, Neurology and Microbiology. Interested individuals should send a CV and a list of 2-3 references to: sergej.djuranovic@wustl.edu

Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at https://postdoc.wustl.edu/policies-benefits/

Contact information:

Sergej Djuranovic, Ph.D.

Associate Professor of Cell Biology and Physiology

Department of Cell Biology and Physiology

Washington University School of Medicine

660 S. Euclid Avenue

McDonnell Science Building Room 514

Saint Louis, MO  63110-1093

Lab website: https://sites.wustl.edu/djuranoviclab/