美国宾大医学院和费城儿童医院博士后职位：干细胞和白血病中核糖体合成与泛素信号研究

美国宾大医学院和费城儿童医院博士后职位：干细胞和白血病中核糖体合成与泛素信号研究

Postdoc fellow – Ribosome biogenesis and ubiquitin signaling in stem cells and leukemia

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to investigate ribosome biogenesis and ubiquitin signaling in hematopoietic stem cells as well as leukemia. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Our recent publications include: Cell Stem Cell, March 11, 2021; Nature communications 9(1): 3915, Sep 2018; Genes & development 31(10): 1007-1023, May 2017; Blood 133(14): 1560-1571, Apr 2019. You can find more of our recent publication and laboratory information in below website.

https://www.med.upenn.edu/apps/faculty/index.php/g275/p8146029

Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, as well as mouse models.

Highly motivated candidates with publication records are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to:

tongw@chop.edu

Wei Tong, Ph.D

Professor of Pediatrics,

Children’s Hospital of Philadelphia,

University of Pennsylvania School of Medicine,

Co-Director, Hematopoietic Stem Cell program,

Institute for Regenerative Medicine at UPENN

Abramson Bldg. 310D,

3615 Civic Center Blvd.,

Philadelphia, PA 19104

Tel: 267-426-0930

Fax: 267-426-5476