法国艾克斯马赛大学免疫学或上皮生物学方向博士后职位

法国艾克斯马赛大学免疫学或上皮生物学方向博士后职位

Postdoctoral Position Is Available At The Centre Of Immunology Of Marseille-Luminy (Ciml) On The...   Description

Organisation/Company: CNRS – Inserm – Aix Marseille University

Research Field: Biological sciences › Biology Medical sciences › Other

Researcher Profile: Recognised Researcher (R2)

Application Deadline: 15/07/2021 23:00 - Europe/Brussels

Location: France › Marseille

Type Of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 01/09/2021

A postdoctoral position i s available at the Centre of Immunology of Marseille-Luminy (CIML) on the role of Interferon Lambda (IFN-λ) in inflammatory bowel diseases (IBD): impact on the regenerative capacity of epithelial cells.

Project: IBD is characterized by a dysregulated immune response that results in damage to the gut mucosal tissues; therefore, an important area of therapeutic interest is promoting healthy mucosal healing. In our lab, we focus on IFN-λ, a cytokine that is of great importance in the protection of mucosal barriers. IFN-λ is known to protect the mucosa from viral infections as well as to down-modulate inflammation, thus avoiding barrier damage. However, its effect on epithelial biology in tissue recovery as well as the nature of the microbial stimuli that induce IFN-λ production in the gut are still undetermined.

In the framework of the FRM project: “Interferon Lambda (IFN-λ) in inflammatory bowel diseases (IBD): impact on the regenerative capacity of epithelial cells ” the successful candidate will be appointed with a fully- funded two-year fellowship. Using both mouse models of IBD and in vitro intestinal organoid technology, he/she will study: a) the relevance of IFN-λ signaling in IECs in the control of tissue restitution. b) the microbial stimuli that govern IFN-λ production in the gut as well as the cellular source of IFN-λ in healthy and diseased mice.

He/she will benefit from the excellent scientific environment of the CIML and its state-of-the-art research facilities. This project will require a wide variety of techniques including growing intestinal organoids, scRNA-seq, microbiology, confocal microscopy, and animal experimentation.

Candidate qualification: We seek a highly motivated, creative and enthusiastic postdoctoral fellow, able to work independently with excellent communication skills. Applicants should have a Ph.D. with at least one first- author publication and a strong background in immunology or epithelial biology.

Basic knowledge of RNAseq and/or microbiome analysis is an asset but not requested.

Application: Candidates should send their application including CV, a brief description of research accomplishments, list of publications, cover letter and contact for at least two referees into a single PDF file to AchilleBroggi(achille.broggi AT childrens.harvard.edu).

Selected candidates will be contacted for an interview.

The starting date is Sep 1, 2021.

Eligibility criteria

Applicants should have a Ph.D. with at least one first-author original research publication.

Selection process

Candidates will be evaluated based on the following criteria:

Academic achievements

Past research experience (internships, master thesis)

Interest to work in a multidisciplinary research environment

Enthusiasm and communication skills

Required Research Experiences

RESEARCH FIELD

Biological sciences › Biology

YEARS OF RESEARCH EXPERIENCE1 - 4

Offer Requirements

REQUIRED EDUCATION LEVEL

Biological sciences: PhD or equivalent

Medical sciences: PhD or equivalent

REQUIRED LANGUAGES

ENGLISH: Good

Skills/Qualifications

We seek a highly motivated, creative, and enthusiastic postdoctoral fellow, able to work independently with excellent communication skills. A strong background in immunology or epithelial biology is required.

Basic knowledge of RNAseq and/or microbiome analysis is an asset but not requested.

Specific Requirements

Deadline for application: July. 15, 2021

Duration: 2 years

On-site or video interviews: Aug. 10, 2021