加拿大多伦多大学玛格丽特公主癌症中心免疫疗法博士后职位

加拿大多伦多大学玛格丽特公主癌症中心免疫疗法博士后职位

Princess Margaret Cancer Centre

Postdoctoral fellow positions, Hirano Lab, University Health Network and University of Toronto

Fully-funded postdoctoral fellow positions in the laboratory of Dr. Naoto Hirano at the Princess Margaret Cancer Centre, University Health Network (UHN) and University of Toronto are immediately available to be engaged in basic, translational, and clinical researches to develop novel immunotherapies for cancer, autoimmune diseases, and autoinflammatory diseases. Our research program aims to provide training opportunities for career development toward future independence in academia or industry. Opportunities for mentoring and leadership experience will be provided and presenting at national and international meetings is highly encouraged. Collaboration with both academia and industry is highly active.

Highly motivated individuals with a recently awarded PhD in immunology, biochemistry, structural biology, stem cell biology, or a related area and strong interest in cell-based immunotherapy are encouraged to apply. Practical experiences with molecular and cellular biology and immunology techniques are required.

Select Publications

1. Sugata K, Matsunaga Y, et al. Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Nat Biotechnol. 2021.

2. Murata K, Nakatsugawa M, et al. Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. eLife. 2020.

3. Benveniste PM, et al. Generation and molecular recognition of melanoma-associated antigen-specific human gamma/delta T cells. Sci Immunol. 2018

4. Kagoya Y, et al. A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects. Nat Med. 2018; 24(3):352-359.

5. Yamashita Y, Anczurowski M, et al. HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway. Nat Commun. 2017; 8:15244.

UHN is a research hospital affiliated with the University of Toronto. The scope of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. University of Toronto is a leading publicly funded university based in the sixth largest city in North America.

Applicants should respond by email with a CV, brief description of research interests, and contact information of three referees in one PDF document to Dr. Naoto Hirano (naoto.hirano@uhnresearch.ca)

Naoto Hirano, MD, PhD

Associate Director for Research

Tumor Immunotherapy Program

Senior Scientist

Princess Margaret Cancer Centre

Professor

Department of Immunology

University of Toronto

Web: https://www.uhnresearch.ca/researcher/naoto-hirano

Web: http://www.immunology.utoronto.ca/content/naoto-hirano

Web: https://oicr.on.ca/investigators/naoto-hirano/