美国圣路易斯华盛顿大学医学院博士后研究职位

美国圣路易斯华盛顿大学医学院博士后研究职位

Postdoctoral fellow at Washington University in St. Louis to study the underlying mechanisms of tetraspanin function during B cell trafficking

Washington University in St Louis Medical School

Location: Saint Louis, MO

Job Number: 7074179

Posting Date: Jan 17, 2021

Application Deadline: Open Until Filled

Job Description

A postdoc position is immediately available for a highly motivated individual to study the underlying mechanisms of how tetraspanin CD53 regulates B cell trafficking using biochemistry and cell biology approaches. To support the study, Dr. Weikai Li’s lab at Washington University in St. Louis has developed multidisciplinary approaches that combine novel mass spectrometry and structural biology methods with biochemistry and cell biology. Recent publications of the lab include those in Science, Science Adv., EMBO J and NSMB. The lab is well funded by five grants from NIH and other foundations, which can support the entire duration of postdoctoral study. More information of the lab can be found at https://weikailab.wustl.edu.

Requirements and Responsibilities

The postdoc candidate should have strong background and publication record in either biochemistry or cell biology, and bring such expertise to the lab. Other possible projects in the lab include:

•       Biochemistry and structure biology (cryo-EM and crystallography) of membrane proteins and complexes as important therapeutic targets in immunology, hematology and cardiovascular biology.

•       The degradation pathway of ferroportin (the only iron exporter) and its protective role of cardiomyocytes.

•       The cellular organization of tight junction formation mediated by claudins and associated molecules.

The lab culture encourages free exploration, and the fellow is welcome to develop their own research projects and strategies that are of mutual interest. High degrees of motivation and independency are greatly appreciated. On the other hand, the PI is always available to provide advices.

Research Environment: The Washington University Medical School is top ranked in the US. The Li lab is well established and equipped in the structural biology, mass spectrometry, biochemistry, and cell biology studies of membrane proteins, and has developed novel methods for these studies, such as live cell footprinting (NSMB 2007) and fast structure determination (Sci. Adv. 2020). Close collaboration with Dr. Michael Gross lab affords us extensive access to mass spectrometry analyses.