瑞典卡罗林斯卡医学院人类肝脏疾病的体外模型研究博士后职位

瑞典卡罗林斯卡医学院人类肝脏疾病的体外模型研究博士后职位

Postdoctoral Researcher in vitro models for human liver disease

Job Description

Do you want to contribute to top quality medical research? Background

The research at our lab The Section of Pharmacogenetics (see https: // ki.se/en/fyfa/sektion-of-pharmacogenetics-mis-lab) at the Department of Physiology and Pharmacology aims to understand the basis for liver diseases and to identify the genetic origin for differences between individuals in drug metabolism, toxicity and drug response. We, in collaboration with others, strive to understand repair of liver injury and to develop novel in vitro systems for predicting drug response and adverse drug reactions as well as to develop In vitro systems for liver disease and their treatment. The research is financed from e.g. ERC, The Swedish Cancer Foundation, EU (H2020), The Swedish Brain Foundation and The Swedish Research Council.

Your mission

We are looking for a postdoctoral researcher who will work with an in vitro model for liver function and disease. The project focuses on use of complex multicellular 3D spheroid systems for identification of interventions of liver diseases like NAFLD, NASH and liver fibrosis. The work includes to produce the liver spheroids from cryopreserved cells, cultivation of these systems and evaluating the effects of different conditions and drugs on disease development and treatment using genetic, genomic, transcriptomic, proteomic andmetabolomic analyses.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

The applicant should have a PhD degree in molecular biology, biochemistry, molecular genetics, physiology or similar. The applicant is expected to have a good understanding of different laboratory techniques with focus on cell biology and molecular biology. Experience of in vitro organoid systems is required.Furthermore, good communication skills and good proficiency in spoken and written English are necessary.

What do we offer?

KarolinskaInstitutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At KarolinskaInstitutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. KarolinskaInstitutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna campus, Biomedicum