美国凯斯西储大学离子通道生物发生与功能研究博士后职位招聘

　　招聘简介：

　　离子通道生物发生与功能的博士后学者

　　·凯西储备大学医学院

　　·地点：俄亥俄州克利夫兰

　　·工作编号：7055630

　　·发布日期：2019年1月30日

　　·申请截止日期：开放至填写

　　职位描述

　　凯斯西储大学医学院生理与生物物理系寻求一位积极性很高的博士后学者，在穆廷伟博士的实验室进行研究（https://physical.case.edu/people/faculty/tingwei-mu/）。根据最新的《美国新闻与世界报道》（https://www.us news.com/best research schools/top medical schools/case-western-reserve-university-04086），凯西储备大学医学院排名为25。

　　MU实验室专注于离子通道的蛋白质质量控制。离子通道蛋白折叠和错误折叠是医学领域的一个新兴领域。我们结合神经科学、电生理学、细胞生物学和生物物理学的方法来确定蛋白沉积网络是如何协调神经受体的折叠、降解、组装、运输和功能的。实验室的另一个研究重点是开发治疗方法，纠正致病性离子通道的错误折叠，作为治疗这种蛋白质构象疾病的治疗策略。

　　英文原文：​

　　Postdoctoral scholars in ion channel biogenesis and function

　　·         Case Western Reserve University School of Medicine

　　·         Location: Cleveland, OH

　　·         Job Number: 7055630

　　·         Posting Date: Jan 30, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks one highly motivated postdoctoral scholar to conduct research in the laboratory of Dr. Tingwei Mu (https://physiology.case.edu/people/faculty/tingwei-mu/). Case Western Reserve University School of Medicine ranks #25 according to the newest US News and World Report (https://www.usnews.com/best-graduate-schools/top-medical-schools/case-western-reserve-university-04086).

　　The Mu lab focuses on protein quality control of ion channels. Ion channel protein folding and misfolding is an emerging field in the medical science field. We use a combination of neuroscience, electrophysiology, cell biology, and biophysics approaches to determine how the proteostasis network orchestrates the folding, degradation, assembly, trafficking and function of neuroreceptors. Another research focus of the lab is the development of therapeutics that correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of such protein conformational diseases.

　　The successful applicant will participate in projects on elucidating the molecular mechanism of ion channel folding, assembly, and trafficking. The posted position will be supported by our newly funded NIH RO1 grant. The successful candidates will be offered competitive salary and benefits packages, as well as considerable professional development opportunities.

　　The candidate is expected to study pharmacology of neurotransmitter-gated ion channels using patch-clamping electrophysiology and track their biogenesis using cellular techniques. In addition, the candidate is expected to use small molecule proteostasis regulators to correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of related neurological diseases.The applicant must have a PhD and/or MD degree in biophysics, neuroscience, cell biology, pharmacology, or related field. Previous experience with endoplasmic reticulum biology, fluorescence techniques, or neuroreceptors-related research is desired, but not required.

　　Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to tingwei.mu@case.edu. Review of applications will begin immediately and continue until the positions are filled.