Postdoctoral Scientist - Neurobiology - Dr William Schafer

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Job Description

Overall purpose:

To work within the Group of Dr William Schafer at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at understanding the molecular and cellular mechanisms of behaviour. Specifically, to undertake research to investigate gene products that play important and conserved functions in the detection of aversive mechanical and thermal stimuli and the control of behavioural states. Key approaches will be to record neural activity using optogenetic indicators, investigate the localisation of neuronal protein complexes by fluorescence microscopy, and analyse expression patterns of neuronal receptors and signalling molecules using multicolour volume whole-brain imaging.

Main duties:

• To undertake research aimed at discovering mechanisms of nociceptive sensory transduction and modulation;
• To identify, develop and apply a broad range of techniques to pursue the research objectives;
• To present scientific work at seminars within the Laboratory and at external meetings;
• To contribute to Laboratory-wide discussions on developments within the field;
• To draft scientific papers, and contribute to the overall preparation of research for publication;
• To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care;
• To assist in the training of PhD Students and other members of the LMB.

Key responsibilities:

• Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan;
• To plan your own work and objectives on a 12 month basis and manage your experimental work within the project along with your Supervisor;
• To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project;
• To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required;
• To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements;
• To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
• To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr William Schafer and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Person Specification

Academic qualifications:

• These should include a PhD in a relevant subject.

Technical skills and expertise:

• Experience of and ability to perform techniques relevant to the project. Particularly useful would be experience of C. elegans molecular genetics and combination of skills in molecular cloning, high-resolution microscopy, immunocytochemistry, and image processing and analysis.

Track record of research:

• This will include achievements, and contributions to published papers.

Other relevant evidence of:

• Commitment;
• Originality;
• Ability to communicate;
• Working with others.

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