美国威斯康辛医学院免疫检查点蛋白如何调节免疫反应方向博士后

Job Description

A postdoctoral fellow position is available in Dr. Li Lily Wang’s laboratory, in the department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI. (https://www.mcw.edu/Microbiology/Wang-Lab.htm).
The overall research focus in the Wang laboratory is to understand how immune-checkpoint proteins regulate immune responses during the development of cancer and develop targeted therapeutics for cancer immunotherapy. Our recent studies have established the role of an immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) in regulating anti-tumor immunity (1 – 4). Currently, we use diverse approaches, including preclinical cancer models, ex vivo cellular analyses, and high-throughput screening assays to address the signaling mechanisms of VISTA and additional immunoregulatory pathways, and develop novel therapeutics for cancer therapy.
We welcome talented and committed candidates with recent Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Lily Wang, Associate Professor, Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, 53226. WI. Phone: (414) 955-7489 Email: lilywang@mcw.edu.

Mission of the Department of Microbiology & Immunology
The mission of our faculty is to conduct innovative and impactful research in Microbiology, Immunology, and Virology and to train students and postdoctoral fellows for careers as biomedical scientists. Our faculty also instruct in the Graduate School of Biomedical Sciences and the Medical School and often collaborate with clinical scientists to facilitate the translation of bench to bedside therapies to treat human diseases. Our students acquire professional training while carrying out independent research projects in microbial pathogenesis and physiology, the immune response, and host interactions with microbial pathogens. Our administrative and research staff strive to support the research, teaching and service activities of our students and faculty. Department website: http://www.mcw.edu/Microbiology.htm

References:
1. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L. (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689 

2. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. Proc Natl Acad Sci U S A. (41):14846-51 

3. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Proc Natl Acad Sci U S A. 112(21):6682-7

4. Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Turk MJ, Hwang ST, Malarkannan S, Wang L. (2017) VISTA regulates Imiquimod-induced skin inflammation via controlling the inflammatory cytokine production and T cell activation. Scientific Reports 7, 1485