英国斯旺西招收分子心脏病学研究员

Research Officer in Molecular Cardiology

Institution: Swansea University Medical School
Job Number: AC02739
Contract: Fixed Term Contract until 14th September 2020
Anticipated Start Date: 2 July 2018
Closing Date for Applications: 17th June 2018
Salary: £33,518 to £38,833 per annum together with USS pension benefits.

Job description

Applications are invited for a post-doc Research Associate to provide comprehensive scientific and technical support to a British Heart Foundation-funded team investigating the “Drug-induced stabilisation of ryanodine receptor to improve calcium handling and cardiac function in arrhythmogenic cardiac disease”. This research is aimed at understanding the molecular, cellular and physiological basis of inherited cardiac disease mediated by the ryanodine receptor protein. Ryanodine receptors are large proteins that enable the release of stored calcium to enter the cytoplasm which triggers myocyte contraction. Inherited RyR2 mutations with an estimated prevalence of 1:10,000, result in (physical or emotional) stress-induced arrhythmias that take the lives of seemingly healthy young people and children. This research will establish the role of ryanodine receptor inter-subunit interactions in the pathogenesis of genetic cardiac disease. Further, it will help to deliver novel drugs that normalise cardiac myocyte calcium handling with potential clinical benefit in arrhythmogenic disease.

The post holder will be part of the Molecular Cardiology group within Swansea Medical School, a leading international group for elucidating the molecular basis of ryanodine receptor dysfunction in arrhythmias and sudden cardiac death. The British Heart Foundation-funded team has extensive laboratory amenities for molecular biology, biochemistry, microbiology, and tissue culture. It also houses comprehensive confocal laser-scanning microscopy and electrophysiology suites for intracellular calcium and fluorescence imaging, and for current recording through intracellular calcium ion channels, respectively.

Informal enquiries contact details and Further Information

Informal enquiries are welcome and should be directed to Dr Spyros Zissimopoulos Spyros.Zissimopoulos@Swansea.ac.uk

For full job details and to apply online please visit our vacancies page at:
Link:http://www.swansea.ac.uk/personnel/jobs/details.php?nPostingID=9838&nPostingTargetID=20892&option=52&sort=DESC&respnr=1&ID=QHUFK026203F3VBQB7VLO8NXD&JOBADLG=UK&Resultsperpage=20&lg=UK&mask=suext

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