瑞典哥德堡分析神经化学博士后

We are looking for a motivated and ambitious Post doc with extensive experience in mass spectrometry preferably within lipidomics or metabolomics.

Subject area description

A pathological hallmark of Alzheimer's disease includes aggregation of amyloid beta peptide in the brain to form extracellular plaques. The exact molecular mechanism underlying AD plaque pathology are still not understood hampering the development of curative treatment strategies. Neuronal lipids have been implicated in AD plaque pathology suggesting a prominent relevance in amyloid plaque formation mechanism. In addition, there is a great need for molecular markers that that reflect different disease mechanisms to facilitate an early and accurate diagnosis. Today there are three CSF biomarkers used for the diagnosis of Alzheimer's disease, but these can only be used quite late in the disease and they have a relatively large overlap between sick and healthy, highlighting the need for more accurate markers that reflect AD pathology.

Job assignments

The candidate will be involved in several projects on investigating Alzheimer’s disease (AD) pathology using advanced mass spectrometry tools such as imaging mass spectrometry and LC-MS/MS for in situ and ex vivo analysis of neuronal lipid species. The main aim is to identify and validate new lipid based AD biomarker candidates for improved AD diagnostics.
Here, the candidate will together with other researchers in the group work on different projects to probe AD disease pathology in transgenic mouse models and human samples and finally summarise and interpret data for scientific publications.

Eligibility

To qualify as a postdoctoral researcher the applicant should hold a PhD in analytical chemistry, biophysics, biochemistry or any other relevant subject related to the project. Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years from the application deadline. Sufficient proficiency in English (oral and written) is mandatory.

Assessment

Candidates will be assessed based on documented scientific experience and knowledge about method development and biological application within mass spectrometry as demonstrated by publications in international, peer-reviewed journals. Experience in lipid chemistry and metabolomics as well as clinical chemistry methods together with previous experience working with complex matrices such as tissue extracts and blood is a particular merit. Further, the ability of the candidate to independently process data and write scientific publications is essential, as is the ability to be flexible and to work independently. During assessment, a strong account will be taken with respect to personal ability and qualifications. Very good proficiency in English (oral and writing) is mandatory.

To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject. Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years from the application deadline.

Employment

The employment is a full-time position for 24 months with placement at the Institute of Neuroscience and Physiology. Start by agreement.