德国彭茨伯格创造新型脑穿梭模块（m / f）博后职位

Roche at Penzberg, near Munich, employees more than 5,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.

Roche is an equal opportunity employer.

In order to develop our Brain-Shuttle technology – the transport of therapeutic proteins into the brain – we are planning to evaluate novel binding modules to increase specificity and efficiency of brain uptake. As a postdoctoral fellow in the Large Molecule Research organization in Penzberg you will generate these binding modules and characterize them in analytical and functional assays. This will involve the use of kinetic modeling as well as molecular-biological, biochemical and cell-biological techniques in close collaboration with the respective departments and with your academic mentor. Specifically, you will
· define kinetic parameters for optimal biological function using in-silico¬ methods.
· clone, express, purify and characterize tool proteins needed for binder generation.
· apply Phage Display panning and screening methods to obtain specific binders.
· develop, refine and carry out biochemical and cell biological assays to characterize specific binders for internalization and transcytosis
· publish novel scientific results in a peer-reviewed journal.

Who you are
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.
· You hold a PhD in biochemistry, biology, pharmacy or a related field.
· You have experience in molecular cloning, recombinant protein expression/purification and a broad knowledge in the field of protein characterization using biochemical and analytical methods
· You have gained some insight into binder generation using display methods.
· Experience in standard cell-biological methods including FACS and fluorescence microscopy would be a plus.
· Due to your strong team spirit you enjoy working in international and interdisciplinary teams and you are willing to learn and to explore new fields.
· Excellent communication skills as well as fluency in English complete your profile.

This position is funded by the Roche PostDoc fellowship and is fixed-termed to 2 years.
We are looking forward to your application!