英国剑桥博士后研究员 - 单细胞分析（疟疾）

Postdoctoral Fellow – Single Cell Analyses (Malaria)
Salary Range: £31,498 to £39,729, plus excellent benefits.
Fixed term for 3 years.

In the Sanger Institute Malaria Programme, we are generating large scale genomic and transcriptomic data and we are looking for postdocs interested in using single cell technologies to ask questions about parasite and vector biology. We are generating thousands of parasite and mosquito single cell transcriptomes and we are looking for competitive candidates interested and experienced in either/both wet lab and large scale data analysis.

Malaria parasites are single celled organisms, and investigating them with single cell technologies is revealing new levels of complexity (see our paper on bioRxiv) in lab strains, and much more remains to be done on these lab parasites. We will also be taking portable single cell technologies (e.g., Seq Well) to endemic countries to understand parasite biology more deeply in the context of natural infections, as well as bringing back natural samples to investigate at the Institute using more standard single cell methods. Additionally, we are applying single cell techniques to important mosquito tissues relevant for malaria transmission to better understand vector/parasite interactions.

Obtained data will be used to address fundamental scientific problems in host-parasite-vector interactions and evolutionary biology as well as practical applications in disease control, e.g. working with public health agencies to prevent the spread of drug and insecticide resistance.

The successful applicant will demonstrate dedication to leading this work while being part of a very large and multidisciplinary team, all of whom are invested in the projects.

Exceptional molecular and/or analytical skills are required as is a strong interest in malaria parasite and/or vector biology. We are multi-disciplinary teams, and the successful applicant will work collaboratively with a range of other specialists in the Programme including wet lab scientists, data analysts and statisticians, and malaria and vector biologists and geneticists, so teamwork and a collaborative ethos are required.

Essential Skills
• PhD in molecular biology, statistics, bioinformatics, population genetics or other relevant area of molecular or quantitative analysis
• Strong analytical and problem solving
• Strong written and oral communication
• Knowledge and experience in a relevant field as evidenced by publication record
• Ability to execute complex analytical projects involving multiple partners
• Ability to deliver high-quality scientific outputs
• Ability to lead an area of work and to work effectively with colleagues leading other areas of work within a team environment

Ideal Skills
• Experience of processing extremely large datasets on parallel computing clusters
• Knowledge of bioinformatic methods for processing next-generation sequencing data or similar
• Strong skills in computer programming for advanced statistical analysis and large-scale data management

Other information
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.