德国海德堡博后职位

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,000 employees in more than 50 specialized clinical departments with roughly 1,900 beds, about 66,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

At the Heidelberg University Hospital, Department of Hematology, Oncology and Rheumatology, we are offering initially for 2 years a

Postdoc position (m/f)

in the research group of Prof. Carsten Müller-Tidow in full-time with the option of further extension.

Starting date: as soon as possible
The salary is related to TV-L

We seek highly qualified individuals who are motivated, flexible, collaborative, detail-oriented, have the ability to multitask, and are committed to research excellence. The successful candidate (m/f) should have a PhD degree or equivalent with a strong background in hematology, molecular biology and/or cell biology.

The work in our research group focuses on stem cells and therapy resistance.We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemo- resistance of AML. To follow this question a broad number of in-vitro- and in vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse.

Tasks:
The postdoctoral fellow will work in a team of enthusiastic biologists and medical scientists with the aim to identify genetic networks in the regulation of human leukemia stem cell activity and to understand the mechanisms of developing and overcoming therapy resistance.

Related Publications:
Göllner, S et al: Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia (AML). Nature Medicine 2017 Jan;23(1):69-78.

Zhou, F et al: AML1-ETO requires enhanced C/D box snoRNA formation to induce self-renewal and leukemia. Nature Cell Biology, April 2017.

Required qualifications:
- PhD in biology, biochemistry or equivalent
- Broad expertise in basic cell- molecular and biochemical techniques (Western blotting, Immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
- Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation-Sequencing, CRSPR/CAS9, shRNA- mediated knock down and genome editing techniques
- Experience and high motivation to work with mice and primary patient cells
- High motivation to work hard in a competitive research field
- Drive independently the experimental and project design
- Rapid understanding and independent analysis of complex data
- Experience in writing scientific reports and papers
- Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)
- Strong communication skills (oral presentations and writing)
- Fluent in written and spoken English