美国加州肿瘤学科学家职位

Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, was founded in 1989 to create advanced, novel medicines to treat diseases with an unmet medical need. We are the pioneer and leader in the discovery and development of antisense drugs. By exploiting various cutting-edge RNA targeting technologies, we are capable of specifically and efficiently targeting any gene of interest, including ones which are not targetable by small molecules or antibodies. We currently have three approved drugs, and a robust pipeline of over 30 drugs in various stages of clinical trials.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.

SR. SCIENTIST- ONCOLOGY

We are currently seeking a qualified, highly motivated individual for the position of Senior Scientist in our Oncology Drug Discovery group. The successful candidate will be a strategic member of a fast-paced and interactive research group evaluating novel antisense cancer drugs.

RESPONSIBILITIES:

• Conception, planning, design, execution and troubleshooting of experiments to support preclinical validation of antisense compounds and their transition into clinical development
• Evaluation and characterization of pharmacological responses to antisense compounds in various in vitro and in vivo cancer systems
• Application of different genetic, molecular biology and biochemical tools to evaluate oncogenic pathways modulation and study mechanisms of drug action
• Other duties as assigned

REQUIREMENTS:

• PhD in Molecular Biology, Cell Biology, or Animal Pharmacology
• Completion of an oncology Post Doc program of at least 2 years
• Attractive* track record of innovative oncology research demonstrated by number of publications in peer-reviewed journals based on authorship order
• In-depth knowledge of molecular and cellular biology of cancer is essential
• Experience with animal handling is required
  Experience with in vivo oncology models (GEMMs, chemically-induced, xenografts and PDX models) is highly desirable
• Proactive scientist who can function both as an independent researcher as well as member within multi-disciplinary teams
• Proficiency in Microsoft Office products and GraphPad
• Excellent organizational skills and multi-tasking abilities
• Proven interpersonal skills as well as strong oral and written communication skills