英国剑桥医学免疫中心肿瘤学研究员职位

Location - Cambridge, UK - 12 month Fixed Term Contract (FTC)

If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a Research Scientist within Oncology Research team at Cambridge, UK you will play a pivotal role in isolating therapeutic antibodies during this 12 month Fixed Term Contract (FTC).

AstraZeneca's vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. As well as other tumour types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalised healthcare and biomarker technologies.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

 

Working in this laboratory based position within the Immuno-Oncology Research group (immune mediated therapies) you will support projects aligned with MedImmune Oncology's key focus areas in T cell-based immunotherapy. You will perform in vitro primary immune assays using human PBMC to support projects in the immune oncology pipeline and in vitro assays using cultured cells lines (e.g. luciferase reporter cell assays).

You will also provide support for tumour studies such as tissue acquisition for ex vivo analysis (e.g. confocal microscopy and flow cytometry), to understand the effect of test substances in complex preclinical models and immunology experiments relevant for cancer immunotherapy. Moreover you will have a strong expertise in techniques for the analysis of immune function and phenotype (e.g. flow cytometry, proliferation, cytokine/chemokine release [e.g. MSD, ELISA], chemotaxis, target cell killing assays) and actively keep up to date with new technological developments.