卢森堡资助博士课程代谢产物2-羟基戊二酸（M / F）的表观遗传效应

The University of Luxembourg is a multilingual, international research University.

The University of Luxembourg has the following vacancy in its Systems Biology Group at the Life Sciences Research Unit, Faculty of Science, Technology and Communication:

Doctoral candidate (PhD student) in Elucidation of the Epigenetic Effects of the Oncometabolite 2-hydroxyglutarate (M/F)

· Ref: F1-070019
· 14-month contract, extendable up to 3 years, 40 hours/week (full time)
· Student status
· Start date: 1st of May, 2017

For a new collaborative project on Elucidation of the Metabolism and Epigenetic Effects of the Oncometabolite 2-hydroxyglutarate Using Yeast Genetics, we are recruiting a PhD student interested to carry out transcriptomic and epigenomic analysis of genetically modified and natural yeast strains and validation experiments using mammalian cells. The project will be carried out as a collaboration between the Systems Biology group at the Life Sciences Research Unit (LSRU) and the Enzymology and Metabolism group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg together with external partners.

The PhD student will be affiliated with the Systems Biology group of Prof. Thomas Sauter and supervised by Dr. Lasse Sinkkonen, the head of the Epigenetics Team. The Systems Biology group integrates computational approaches and experimental biology to understand cellular function and gene regulation in development and disease at the genome-wide level. In addition, the student will work closely with Dr. Carole Linster and a newly recruited post-doc at the Enzymology and Metabolism group to take an interdisciplinary approach combining transcriptomic and epigenomic analysis with yeast genetics, metabolomics and biochemical analysis to identify epigenetic and gene regulatory changes induced by the oncometabolite 2-hydroxyglutarate.

For further information, please contact Dr. Lasse Sinkkonen at lasse.sinkkonen@uni.lu

Your Role

· Carry out research and prepare a doctoral thesis in Epigenetics/Biochemistry
· Perform RNA-seq and ChIP-seq experiments with various yeast strains
· Carry out cell culture and experiments with biochemical and molecular biology techniques in yeast and mammalian cells
· Contribute to the computational analysis of deep sequencing data
· Actively work with the collaborators to integrate the obtained results
· Contribute to the teaching activities at the University of Luxembourg

Your Profile

· Master in biochemistry, molecular biology, bioinformatics, or related discipline
· Experience in experimental lab work and cell culture is expected
· Previous experience in working with the model organism Saccharomyces cerevisiae will be an advantage
· Strong interest in bioinformatics and computational analysis will be an advantage
· Excellent working knowledge of English is required
· The candidate will be integrated into a collaborative environment and needs to have excellent communication skills

We Offer

· Fully funded position
· An exciting international and interdisciplinary research environment
· Modern and well-equipped laboratories
· Training in state-of-the-art methods and analysis tools in yeast genetics, metabolomics and functional genomics
· Travel opportunities to visit workshops, scientific conferences and collaborators
· The University offers highly competitive salaries based on the candidate's experience and is an equal opportunity employer.

Further Information

Applications should be written in English and contain the following documents:

· Detailed Curriculum Vitae including a list of publications (if any)
· Cover letter mentioning the reference number
· Description of past research experience and future interests
· Transcript of grades from all university-level courses taken
· Names and contact information from three referees