瑞典哥德堡博士后研究员结构和生物物理学

At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expert ise and build your skills. So if you're curious about what science can do, come and make a difference.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You'll work with some of the most knowledgeable technology experts in the industry, all collaborating on high-profile drug discovery projects. With a wide range of responsibilities, from sample management and screening to bio-reagent supply, the opportunities to develop your expertise here are limitless.

Main duties and responsibilities

PostDoc long title: Functional, biophysical and structural characterisation of a multicomponent transcription factor complex.

Nuclear hormone receptors are ligand activated transcription factors that are critical for both development and a broad range of physiological processes. We're looking for a talented postdoctoral scientist to join our Post Doc Programme to study the structure and function of a highly important full-length receptor in complex, state-of the art ligands and link this information to broader mode of action studies for active clinical projects. In addition, you'll take part in a comprehensive training programme with a focus on drug discovery and development.

You'll gain in-depth receptor experience from extensive discovery projects and technical expertise from both AstraZeneca and the academic collaboration laboratory at CBI.

Specifically, you'll design, express and purify a broad range of receptor constructs across several expression systems, as well as characterising ligands with different pharmacological profiles using biophysical techniques and functional assays. You'll also determine complex structures with either X-ray crystallography or other complementary techniques such as SAXS and high-resolution cryo-EM, and explore the allosteric pathways in between the ligand binding function and different DNA response elements and co-regulator proteins. Presenting your results at scientific conferences and writing/publishing scientific papers in high-quality, peer-reviewed journals is expected.

Essential requirements

• PhD and/or MD in biochemistry, biophysics or structural biology
• Significant experience of protein expression methods using mammalian and insect cells
• Strong background in construct design, molecular biology and protein purification
• Familiarity with biophysical and structural techniques
• Genuine understanding and experience of different assay technologies
• Strong organisational and interpersonal skills
• A proven record of work published in reputable scientific journals.

Desirable requirements

• Experience of working with the following technologies: Protein Crystallization, X-ray crystallography, Small Angle X-ray Scattering, Electron Microscopy, Isothermal Titration Calorimetry and Surface Plasmon Resonance
• Experience of expressing and purifying challenging protein complexes
• Experience of working with DNA binding proteins.