英国剑桥博后职位DNA损伤反应和细胞毒性T细胞

At AstraZeneca we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you're curious about what science can do, th en you're our kind of person.

Cancer is one of the greatest challenges facing medical science today. In our Oncology Team, you'll push the boundaries of science every day to overcome that challenge. We've been at the centre of some of the biggest breakthroughs in oncology. In lung cancer, for example, we've brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We're also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques and a next-generation sequencing platform for companion diagnostics in oncology. But we're not stopping there. With a world-class pipeline and some of the best experts in the industry, we're in a great position to develop even more innovative therapeutic approaches.

Main duties and responsibilities

PostDoc long title: Understanding mechanisms of innate and acquired resistance to BH3 mimetics and optimization of their therapeutic use in cancer

We have an exciting opportunity to determine the mechanistic effects of small molecule DNA damage repair pathway inhibitors on cytotoxic T cell function using state-of-the-art assay and imaging systems.

You'll evaluate the effects of inhibiting key DNA damage repair pathways on in vitro human T cell function using AstraZeneca's industry-leading portfolio of small molecule DDR inhibitors. This will involve investigating the effects on mechanism and kinetics of T cell immune synapse formation and function, using advanced 4D-in vitro microscopy and imaging. At the same time, you'll use these and other techniques to evaluate coordinate effects on key signaling mechanisms and metabolic functions.

Drawing on your existing scientific and technical expertise in immunology, including in vitro functional and signal transduction assays, you'll advance our scientific understanding of the interface between the DNA damage response and T cell immunology. You'll also have the opportunity to work both in a leading academic immunology research group and as an AstraZeneca employee, while developing your understanding of pharmaceutical drug development as part of our vibrant post-doc and scientific community.

Essential requirements

• PhD and/or MD in immunology or a related area of biology
• Understanding of T cell receptor biology and downstream signalling pathways
• Experience of a range of immunological assays, including in vitro activation of immune cell populations, measurement and interpretation of assay endpoints, including flow cytometry, cytokine measurement.

To apply for this position, please click the apply link below.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based. The role will be based at Cambridge, UK with a competitive salary on offer

Opening date of advert: 17th February 2017

Closing date of advert: 18th April 2017