瑞典哥本哈根分子肿瘤博后职位

2 Post doc positions in molecular cancer research in the Sørensen Group at BRIC, University of Copenhagen

2 post doc positions are open in Claus Storgaard Sørensen’s group at BRIC, University of Copenhagen. The positions are for highly motivated researchers with a desire to unravel new pathways and factors important for breast cancer development with potential for therapeutic intervention. Project 2 is part of a newly established international programme on novel familial breast cancer factors.

Our research/The group
The goals of the current projects are to understand how familial breast cancers arise as well as identifying weaknesses within malignant cells that can be exploited in the clinic to manage cancer (see the following recent publications, pubmed IDs: 27515922; 27323328; 27113759; 26805514; 25953507). Our group consists of ten dedicated researchers, and we have excellent research facilities in modern laboratories. More information on the Sørensen group on http://www.bric.ku.dk/research/Sorensen_Group/

Projects

Project 1
The project aims to unravel new factors in DNA damage checkpoint control with focus on the S-phase checkpoint, that slows DNA replication when the genome is damaged. This checkpoint is deficient in many cancers. We have identified to new checkpoint factors operating in response to ionizing radiation, and we will now unravel the functional pathways and molecular mechanisms. The experimental focus will be on biochemical and cell biological approaches, including CRISPR-Cas9 modified cell models.

Project 2
Our breast cancer consortium has applied exome sequencing to identify new factors that guard against breast cancer. The post doc will run medium-scale siRNA screens and validate high scoring factors with CRISPR-Cas9 modified cell models. The post doc will then unravel high scoring factors functional and mechanistic roles with focus on biochemical and cell biological approaches.

Start: Preferably May 1st 2017 or after agreement
Duration: Project 1 is for 2 years; Project 2 is for 3 years

Qualifications
We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:
• A PhD in Life Sciences with focus on cancer biology, biochemistry or similar
• A desire to make a difference through highly dedicated research
• Documented Experience in cell biology, molecular biology, and biochemistry
• Preferred candidates have experience in generating CRISPR-Cas9 cell lines
• Knowledge of genome maintenance pathways, cancer genetics and cancer biology
• Excellent English skills written and spoken