美国免疫学和癌症纳米技术博后职位

The Steinmetz Laboratory at Case Western Reserve University School of Medicine |steinmetzlab.com | is seeking talented post-doctoral fellows to develop and study a virus-based nanotechnologies targeting cancer.

Nanoscale engineering is revolutionizing the way we prevent, detect and treat diseases. Viruses are playing a special role in these developments because they can function as prefabricated nanoparticles naturally evolved to deliver cargos to cells and tissues. Our laboratory has developed a library of plant virus-based nanoparticles; through structure-function studies we are beginning to understand how to tailor these materials appropriately for biomedical applications. Through synthetic biology, we have developed virus-based delivery system carrying contrast agent and/or therapeutic cargo enabling therapeutic applications targeting cancer and cardiovascular diseases. Another avenue is the development of virus-like particle platforms for cancer immunotherapy. For some references, we would like to highlight the following publications:

• our situ vaccination technology Nature Nanotechnology 2016, 11, 295-303,
• drug delivery system ACS Nano 2016, 10, 4119-4126,
• and molecular imaging probes Nano Letters 2014, 14, 1551-1558.

In particular, we seek to hire talented post-doctoral candidates with expertise and interest in:
(i) Molecular imaging and drug delivery
(ii) Cancer Immunotherapy

Specifically the projects will entail the molecular engineering of plant virus-based nanotechnologies and their evaluation in tissue culture and mouse models. One project will focus on the application of virus-based probes for molecular imaging and drug delivery; while another direction is the application of virus-based tools for cancer immunotherapy. The work will include genetic manipulation, bioconjugation, protein expression in bacteria and plants, self-assembly of nanoparticle complexes, nanoparticle characterization such as TEM, ICP, gel electrophoresis, UV/Vis, etc. Nanoparticle probes will be evaluated in tissue culture and in preclinical animal models. Work with include biodistribution, in vivo and ex vivo imaging, immunological investigation by immunohistochemistry and flow cytometry.

We seek highly motivated, creative scientists, who enjoy an interdisciplinary, open, and collaborative environment. Applicant qualifications include a strong background in any of the following areas: molecular biology, nanotechnology, materials characterization, microscopy and spectroscopy, bioconjugation chemistry, virology, cell biology, immunology, preclinical studies, in particular a strong background in multi-color flow cytometry and immunology as well as experience with mouse models would be desired.

The candidate should have a PhD in Immunology, Molecular Biology, Biotechnology, Virology, Chemistry, Biomedical Engineering, Pharmacology, Pharmaceutical Sciences, or related fields. Post-doctoral research experience is not required and not preferred. The candidate may supervise laboratory graduate students and undergraduate students in conducting sample preparation, experimental design and data analysis of a variety of projects. The candidate is expected to develop and execute research projects and will have an opportunity and support to write fellowship and grant applications to foster their career development.