Our group is interested in comparative analyses of normal lymphocyte development and malignant transformation towards leukemia. We cover research areas with relevance to both Immunology and Hematology/Cancer Biology. Our research involves experiments with primary human leukemia cells, leukemia and stem cell transplantation models, mouse genetics, classical molecular and cell biology, a strong emphasis on signal transduction and large-scale data analysis and computational biology.
Methods/Techniques:
Flow cytometry, mass spectrometry/quantitative phospho-profiling, CyTOF, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing andRNA-seq-analysis of clonal evolution of leukemia, pre-clinical drug testing in xenotransplantation models.
Examples of our recent work:
1. Shojaee S et al. Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia. Cancer Cell. 2015; 28:114-128.
http://www.sciencedirect.com/science/article/pii/S1535610815001841/pdfft?md5=2eda98a972e36350efc3d6a2962930ce&pid=1-s2.0-S1535610815001841-main.pdf
2. Swaminathan S. et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nature Immunol. 2015;16: 766-774.
http://www.nature.com/ni/journal/v16/n7/pdf/ni.3160.pdf
3. Chen Z. et al., Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015; 521:357-361.
http://www.nature.com/nature/journal/v521/n7552/pdf/nature14231.pdf
4. Geng H. et al. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015; 27: 409-425.
http://www.sciencedirect.com/science/article/pii/S1535610815000537/pdfft?md5=de304267b4862c5b82dc8d1f81d44f7a&pid=1-s2.0-S1535610815000537-main.pdf
5. Shojaee S et al., PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nature Med. 2016; 22: 379-387
http://www.nature.com/nm/journal/v22/n4/pdf/nm.4062.pdf
Qualifications:
Genuine enthusiasm for science, willingness to think beyond established concepts and to try and learn new experimental and analysis tools. The lab takes a team science approach, so being a nice person and is important as well.
Your application should include in one single PDF:
(1) brief motivation statement, (2) CV and (3) coordinates of three scientific mentors (references).
Contact information:
Markus Müschen, MD-PhD
Markus.muschen@ucsf.edu
http://cancer.ucsf.edu/people/profiles/muschen_markus.3312 |
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ucsf.edu
