英国弗朗西斯·克里克研究所招聘细胞生物学博士后

This is a full-time fixed term position for 4 years on Crick Terms & Conditions of Employment

We seek a talented and motivated postdoc in Molecular and Stem Cell Biology to join our group.

This position is available in Dr Dominique Bonnet’s laboratory. The lab works on human normal and leukaemic stem cells and the role of the microenvironment: https://www.crick.ac.uk/research/a-z-researchers/researchers-a-c/dominique-bonnet/

Project Summary

The group is interested in studying normal human Haematopoietic Stem Cells (HSCs) and Leukaemic Stem Cells (LSCs). At present we are investigating the relationship between normal HSCs, LSCs and their microenvironment. For this we have developed in vivo imaging techniques allowing us to visualise and define normal and leukaemic stem cells niche in vivo as well as 3D scaffold that mimic the HSC microenvironment. With these tools we hope to dissect the role of different components of the stem cell niche and see whether we can intervene in this niche to expand normal stem cells and eradicate LSCs. All these projects should shed light into pathways or interactions that are more specifically used by LSCs and where therapeutic intervention might be developed. Other projects involved bar-coding of HSCs, ex vivo expansion, dissecting molecularly human HSC heterogeneity.

About Us

The Francis Crick institute is an entirely new institute with a distinctive vision of how biomedical research is conducted. It is one of the most significant projects in UK biomedical science for a generation. The institute’s labs have an international reputation for cutting edge research into basic biology and are committed to training the next generation of research scientists.

On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose built research centre in St. Pancras, which will house some 1,500 staff.

Person Specification

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

Key Skills:

Essential

• PhD in a relevant discipline is essential
• Practical knowledge of molecular biology techniques (including Chip-Seq, Chip-Chip)
• A proven ability to work effectively as part of a team, in particular ability to interact positively with project co-workers
• A proven ability to organise and prioritise own work
• Good communication skills
• A High level of computer literacy, including all MS Office applications and literature searches
• Ability to communicate with others where English is not the first language
• Abilitty to present their work at national and international meeting
• Previous experience in multi-colour FACS analysis, molecular and stem cell biology, Animal modelling and Lentiviral virus work

Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

For any questions, please contact us on jobs@crick.ac.uk or Dr Dominique Bonnet (dominique.bonnet@crick.ac.uk)

How to apply: Please submit your application via https://Jobs.crick.ac.uk