西班牙国立癌症中心肿瘤与神经生物学研究博士后职位

These three aims will be applied to develop innovative therapies targeting cancer-induced alterations of the brain microenvironment. Specifically the research project will exploit the heterogeneity present within the reactive glia where we have identified subpopulations of reactive astrocytes by de novo expression of transcription factors (TF) present in multiple experimental models and human samples of brain metastasis from lung and breast cancer. Generated conditional mouse models with TFs knocked out will allow defining their contribution to the establishment and maintenance of brain metastasis, understanding their origin within the heterogeneous astrocyte population as well as interrogating downstream targets using novel in vivo approaches to discover those critical in the generation of a metastatic niche.

The position is funded. However candidates are expected to obtain their own funding using national and international calls for postdoctoral fellowships. Consequently this position requires experienced researchers with an excellent track record (recent main author publications during the last 2 years published in high impact journals/ leading journals in the respective field) that qualify to apply for competitive funding. Our laboratory develops projects combining Neuroscience and Cancer Biology to study fundamental aspects of metastatic tumors in the brain using a large variety of mouse models and human samples. Candidates with probed experience in these scientific fields, including cell culture (cancer cells and brain primary cells), mouse models, in vivo/ ex vivo brain manipulations, metastasis assays are encouraged to apply. Complementary expertise in bioinformatics and functional genetic screens will be required for the project and thus positively evaluated.