The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).
In higher eukarayotes, proteins that lack apparent folded structure enriched in many vital processes. The group of Dr. Lemke at the EMBL studies interactions between intrinsically disordered proteins and structured proteins in vital cellular processes, such as nuclear transport. Since such highly dynamic systems are inaccessible by most conventional approaches, the group applies a multidisciplinary approach combining single molecule, microfluidics and super-resolution techniques with chemical biology tools.
As part of the 5 year ERC funded ERC project “Next generation Single Molecule Protein Fluorescence” we are now looking for a postdoctoral fellow with a strong interest in further expanding quantitative single molecule technologies to understand the molecular mechanisms of IDPs. Furthermore, we aim to address fundamental limitations of single molecule spectroscopy and microscopy with respect to working on complex biological questions, using new technology development in microfluidics.
The project is ideally suited for candidates with a previous background in microfluidic engineering, related lab-on-a chip approaches and/or advanced fluorescence techniques. Experience in biochemistry and/or mammalian cell culture and respective microscopy is helpful. However, most important is an interdisciplinary interest and the ability to tackle a biological problem with a combination of techniques, ranging from sample preparation via measurements on custom-built equipment to advanced computational analysis. A general strong interest in quantitative approaches towards biological problems is essential. Since EMBL offers excellent training in various aspects of these research topics, high interest and motivation are the main selection criteria and candidates from other disciplines that want to venture into these areas are explicitly welcome to apply.
The group of Dr. Lemke is embedded into the Structural and Computational Biology as well as the Cell Biology and Biophysics Units at the EMBL, offering a large range of groups spanning various techniques from the molecular to the systems level. Applicants should feel comfortable to work in such an interdisciplinary and international environment. |
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