美国国立卫生研究所（NIH）招聘表观遗传学和RNA拼接研究博士后

Postdoctoral Position in Epigenetics and RNA splicing at the NIH : Bethesda, MD, United States

Postdoctoral Position in Epigenetics and Pre-mRNA Splicing.

A post-doctoral position is available to study the relationship between chromatin structure and alternative pre-mRNA splicing. The Oberdoerffer laboratory is interested in the establishment and functional impact of intragenic chromatin structure on pre-mRNA processing, with a specific focus on DNA methylation (Nature, 479:74-79, 2011; EMBO J, in press). The available position will examine whether 5-methylcytosine and its oxidation derivatives directly influence splice site choice through modulation of RNA polymerase II elongation and/or splicing factor recruitment. The possibility of crosstalk between DNA methylation and co-transcriptional modification of RNA will also be explored. These and related questions will be examined at the genome-wide level through integrated ChIP-, MedIP-, CLIP- and RNA-seq in a cellular model of development. In addition, emerging associations will be explored in detail through classical and novel molecular bio and biochemical approaches in vitro and at defined genomic loci. For more information: https://ccr.cancer.gov/Laboratory-of-Receptor-Biology-and-Gene-Expression/shalini-oberdoerffer.

The successful candidate will join a highly integrated team of bench and computational scientists with common research interests. Applicants with direct expertise in biochemistry, molecular biology or computational biology related to RNA or chromatin research will be considered. Candidates with experience in CRISPR/Cas9 technology or bioinformatic analysis of large genome-wide datasets are especially encouraged to apply. Applicants must be strongly motivated, possess a Ph.D. or equivalent and have no more than two years of post-doctoral experience.

The Center for Cancer Research (CCR) is the intramural research component of the National Cancer Institute (NCI). CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, provides extensive opportunities for collaboration, and allows scientists and clinicians to undertake high-risk, high-impact laboratory- and clinic-based investigations. Investigators are supported by a wide array of intellectual, technological, and research resources, including animal facilities and dedicated, high-quality technology cores in areas such as imaging/microscopy, chemistry/purification, mass spectrometry, flow cytometry, genomics/DNA sequencing, transgenics and knockout mice, arrays/molecular profiling, and human genetics/bioinformatics. For an overview of CCR, please visit http://ccr.cancer.gov/.

Interested individuals should send a curriculum vitae and bibliography, a brief summary of research interests and accomplishments, scientific administrative experience, and the names and addresses of three references to:

Dr. Shalini Oberdoerffer, Investigator
LRBGE, National Cancer Institute
E-mail: shalini.oberdoerffer@nih.gov

DHHS, NIH, and NCI are Equal Employment Opportunity Employers