Postdoctoral Researcher in DNA Repair and Genome Stability : Philadelphia, PA, United States

Postdoctoral Researcher in DNA Repair and Genome Stability, laboratory of Dr. Roger Greenberg at the Perelman School of Medicine at the University of Pennsylvania.
The laboratory of Dr. Roger Greenberg within the Cancer Biology Department at the University of Pennsylvania is seeking highly motivated postdoctoral researchers interested in fundamental mechanisms of DNArepair. Our research group has pioneered novel approaches to visualize and interrogate the molecular events responsible for DNA double-strand break recognition and repair in mammalian cells. We pursue these basic questions at the biochemical, genetic, and cell biological levels, and have successfully related molecular mechanisms of DNA repair to genetic causes of cancer susceptibility and response to therapy. As a focal point to interrogate these interrelationships, we are devoted to the elucidation of BRCA1- and BRCA2- dependent homologous recombination DNA repair mechanisms and their roles in breast and ovarian cancer susceptibility. We have more recently developed an additional focus on cancer associated telomere length maintenance mechanisms that rely on a specialized form of homologous recombination. We utilize state-of-the-art biological approaches to understand: (1) how BRCA1 and BRCA2 recognize and function at DNA damage sites, (2) how DNA repair pathway choice affects response to anti-cancer therapies, and (3) how DNA damage responses affect transcription.
We are looking to appoint an enthusiastic and motivated Postdoctoral Researcher in these areas. Candidates will have a PhD in Biochemistry, Molecular Biology, or related Biological Science and an extensive publication record in these areas.