丹麦哥本哈根大学招聘哺乳动物细胞基因组维护路径方向博士后

Two postdoc and one assistant professor for research in genome maintenance pathways in the Sørensen Group at BRIC, University of Copenhagen

Postdoc positions are open in Claus Storgaard Sørensen’s group for highly motivated researchers with a desire to investigate key genome maintenance pathways in mammalian cells.

Our research/The group
The goal of our studies is to understand the mechanisms responsible for maintenance of genomic stability in mammalian cells with a particular focus on disease relevant pathways (see the following publications from this year, pubmed IDs: 26555168; 25953507; 25772361; 25557911). Our group consists of ten dedicated researchers, and we have excellent research facilities in modern laboratories. We offer excellent working conditions with exciting possibilities in a young, dynamic and international research environment. More information on the Sørensen group on http://www.bric.ku.dk/research/Sorensen_Group/

The research projects

Assistant professor: The assistant professor will develop a new method to detect DNA double strand breaks, the most lethal genotoxic lesion. This is based on recent findings in our team and involves structural analysis of new DNA double strand end binding probes. Furthermore, the assistant professor will participate in structural analysis of new genome maintenance proteins in collaboration with other members in the team. This second part also involves in vitro interaction and activity assays.

Specific qualifications: Documented experience in structural biochemistry including protein purification and structural analysis of proteins.

Start: Preferably early 2016 or after agreement

Duration: 2 years

Postdoc 1: The postdoc will identify new epigenetic targets in Non-Hodgkins Lymphoma (NHL) with focus synthetic lethal interactions. The project is a close collaboration with clinical NHL researchers from Rigshospitalet, Copenhagen. We use RNA interference screening in NHL cell lines followed by CRISPR/Cas9 targeting to identify and characterize putative new targets. Two already identified lead targets will serve as initial focus for characterization.

Specific qualifications: Documented experience cell biology and biochemistry, including siRNA depletion CRISPT/Cas9 deletion, mutagenesis and immunoblotting, confocal microscopy.

Start: Preferably early 2016 or after agreement

Duration: 2 years

Postdoc 2: The postdoc will characterize a novel epigenetic genome maintenance pathway recently identified in our team. This project will include RNA and ChIP sequencing as well as proteomic approaches. In a parallel approach, the post doc will dissect the biological role of this new pathway.
Specific qualifications: Documented experience cell biology and biochemistry with focus on epigenetic analysis, including ChIP and histone modification analysis.

Start: Preferably early 2016 or after agreement

Duration: 22 months

NB: In your letter of motivation, please state clearly which of the three positions you are applying for.

General qualifications
We expect you to be a documented highly motivated, skilled, and highly ambitious scientist with the following key qualifications:
• A PhD in Life Sciences
• Outstanding qualifications as outlined in the research projects
• Excellent English skills written and spoken
For further information regarding the positions, please contact Associate Professor Claus Sørensen on e-mail: claus.storgaard@bric.ku.dk
Place of employment
The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighbouring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/
Please read more about BRIC on http://www.bric.ku.dk/

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 32.095 DKK/ca. 4.250 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Application
Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on http://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:
1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.
Letters of recommendation
Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on jobs@bric.ku.dk with subject “name candidate-Sorensen-3xpostdoc-Nov2015”; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 20 December 2015.

We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

The further process
Shortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised.
Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement.

You can read about the recruitment process at http://employment.ku.dk/faculty/

BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

The University of Copenhagen actively influences current and future generations through excellent research, education and co-operation. UCPH is one of the highest ranked universities in Europe and is Denmark’s oldest university, founded in 1479. Today, the University has 40,000 students and 9,000 employees affiliated across six faculties: humanities, law, natural sciences, social sciences, health sciences and theology.