英国桑格研究院统计遗传学博士后职位

Salary £30,202 to £37,860 dependent on experience

Fixed Term Contract: 3 years

We are currently seeking applicants for a Statistician position at the Soranzo group (https://www.sanger.ac.uk/research/faculty/nsoranzo/) at the Wellcome Trust Sanger Institute (WTSI located on the Wellcome Trust Genome Campus near Cambridge in the UK). The post will suit an ambitious and talented statistician, who is interested in applying their skills in the genetics/genomics field.

The successful candidate will be involved in statistical analyses combining genetic array and next-gen sequencing data with hematological indices, iron biomarkers and other cardiovascular outcomes and risk factors, including ‘multi-omics’ (eg metabolomics, lipidomics, proteomics) data, assayed in the 50,000 person INTERVAL Study. The aims of this work are to identify causal variants and novel biological pathways influencing blood cell formation, donation outcomes, and donor health, and ultimately to translate findings into clinical practice.  Major emphasis will be placed on leading original analyses and manuscripts, career development and transition toward an independent research career. The successful candidate will be expected to produce high-impact first author publications.

The selected candidate will work with an interdisciplinary team of scientists, bioinformaticians and statisticians at the Wellcome Trust Sanger Institute (WTSI). The WTSI, which is based on Europe’s largest genomics campus (near Cambridge), focuses on understanding the role of genetics in health and disease. Dr Nicole Soranzo leads a group focusing on the use of quantitative intermediate traits (such as haematological and metabolomic traits) to unravel novel mechanisms underlying common, complex diseases such as cardiovascular disease. The project will also involve collaboration with the Cardiovascular Epidemiology Unit (CEU), Department of Public Health and Primary Care, University of Cambridge. The CEU conducts world-leading interdisciplinary research with a major focus on the prediction and prevention of cardiovascular diseases using studies conducted in more than 2.5 million participants.

Essential Skills

The post-holder will have: (1) a relevant post-graduate statistical training e.g. PhD in Statistics, Statistical Genetics, Medical Statistics, Biostatistics, Mathematics, or similar or equivalent experience (2) a sound understanding of statistical concepts (3) experience of manipulating and managing large datasets (4) strong quantitative (in silico) analysis skills; (5) experience of assessing and/or developing statistical methods; (6) and experience using relevant statistical software: Stata or R. Experience of analyzing genetic data is highly desirable, but not essential. The post-holder should have excellent organisation and communication skills.