Postdoctoral Fellow in Computational Genomics

A computational position has become available which involves developing computational and statistical methods in a project within the Cancer Genomics Programme.

The post holder will have responsibilities to develop computational and statistical methods for a project exploring somatic mutations associated with aberrations in DNA repair pathways. We are generating human iPSC lines from patients with germline mutations in DNA repair/replication pathways and generating parallel CRISPr/CAS-9 edited lines of the same genes. The over-arching objective is to explore mutational signatures in the context of the biological mechanisms associated with DNA repair, by integrating cellular/molecular approaches with genome-wide assays including genomic sequencing, RNA-seq and ChIP-seq.

Essential Skills

We welcome candidates with a solid expertise in statistics/computational biology/population genetics or genomics/computer science/physics, in addition to strong quantitative skills. Programming skills and experience in handling large datasets is essential. Candidates with experience in genome-wide assays and genomics/molecular biology are encouraged to apply. The ability to communicate effectively, organize your own time and work independently are essential.

Other information

A detailed role profile and further information regarding the new program can be found on our website at: http://www.sanger.ac.uk/

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Please include a covering letter and CV with your application.