美国乔治城大学生命科学研究博士后职位

Postdoctoral Fellowship in Metabolomics

Georgetown University Medical Center has made a major commitment to metabolomics as a critical component to our systems biology and systems medicine initiatives. A funded position is now available through the Dept. of Biochemistry and Molecular & Cellular Biology in our program for a metabolomics postdoctoral position. An important focus is on stress and inflammatory signaling networks at the metabolomics level. The position also will involve development of molecular markers for injury responses and disease processes such as radiation injury, and inflammatory bowel disease. There is also an additional focus on microbiome metabolism. Our mass spectrometry facility has assembled state-of-art instrumentation for metabolomics and is a Waters Center of Innovation. This metabolomics program is funded to carry out a variety of studies in animal models, patient samples, and the recruit will have opportunities to participate in and build on these projects. The recruit will participate in study design, sample preparation, mass spectrometry data analysis, and manuscript preparation. Experience in mass spectrometry (LCMS and/or GCMS) is required, and background in related areas, such as analytical chemistry, biochemistry, and/or bioinformatics, will also be taken into consideration.

Responsibilities: 
Sample preparation for mass spectrometry (MS) analysis, including preparation of chemical standards and
biological samples for targeted and untargeted MS analysis. Occasionally preparing samples under biological cabinets, and performing solid-phase extractions to remove contaminants.
Pre-processing of metabolomic data using MassLynx, Progenesis, XCMS, etc.
Data analysis using online and in-house statistical software packages to draw biologically relevant conclusions.
Operating UPLC-QTof (Waters Xevo G2) and tandem quadrupole (Waters TQ-S) for untargeted and targeted metabolomics and lipidomics in data independent mode.
Using available databases to identify molecular species.
Writing, communicating, and presenting methods and experimental data, preparing figures for presentations and manuscripts.
Minimum requirements:
PhD in life sciences
Background in mass spectrometry (LCMS and/or GCMS), preferably trained in metabolomic sample preparation from various sample matrices, and chromatographic methods.
Strong skills in MS data analysis (preferably metabolomics data), and biological interpretation of results
Strong verbal and written communication skills.
Applicants should be self-motivated, have critical thinking and independent working skills, possess strong
communication skills, and the ability to work with others in a collaborative research environment.