美国加州大学圣地亚哥分校招聘蛋白质组学和蛋白质体内平衡博士后

Applications are invited for a junior or senior postdoctoral position in the laboratory of Eric Bennett in the section of Cell and Developmental Biology at the University of California, San Diego (http://labs.biology.ucsd.edu/bennett/). Applicants with previous postdoc experience are encouraged to apply.

Research in the Bennett lab uses integrative approaches ranging from biochemistry to quantitative proteomics to investigate how the ubiquitin-proteasome system regulates protein homeostasis. Protein homeostasis dysfunction has been implicated in a wide array of aging associated disorders from cancer to neurodegenerative disease.

Projects within the Bennett lab are aimed at uncovering and characterizing novel ubiquitin-dependent regulatory mechanisms that govern the response to protein homeostasis stress. To accomplish this, the lab also develops and utilizes quantitative proteomics methods to interrogate proteome dynamics in response to genetic and pharmacological disruptions of the ubiquitin-proteasome system.

Successful applicants will have the opportunity to interact and work with biotech companies through existing collaborative industry sponsored research projects.

The following are examples of research in the Bennett lab.

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins.
Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ.
Mol Cell. 2015 Jul 2;59(1):35-49

Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40

Successful applicants should:
1. Either currently have a Ph.D. degree or will achieve a Ph.D. prior to initiating work
2. Have demonstrable expertise in at least a subset of the following: mammalian cell culture, protein biochemistry, molecular biology, or quantitative mass spectrometry.
3. Have experience with mass spectrometry-based proteomics in terms of sample preparation, chromatography, instrument methods, data acquisition and analysis. Preference will be given to applicants with experience in post-translation modifications, in particular ubiquitylation.
4. Enjoy a dynamic work environment with many opportunities for exciting collaborative research with labs both inside and outside UCSD.

Self-motivated individuals are encouraged to send their CV, a brief (1-2 paragraphs) statement of interest and contact information of two references to Eric Bennett, e1bennett@ucsd.edu….