比利时鲁汶大学免疫学博士后职位

Our lab (lab of Mucosal Immunology) is mainly interested in the molecular mechanism responsible for the tolerogenic imprinting of intestinal immune cells crucial to preserve intestinal immune tolerance and prevent chronic inflammatory pathology of the gastrointestinal tract. We are in the Department of Clinical and Experimental Medicine at the Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven. TARGID is a leading centre for gastrointestinal research in the Europe. TARGID aims to provide insight in physiological and pathophysiological mechanisms in order to identify new targets ultimately leading to better therapies for gastrointestinal disorders such as functional and inflammatory bowel diseases. To this end, pre-clinical and clinical expertise is combined with state of the art technology to provide top quality research and to create a stimulating setting for bidirectional interaction between basic and clinical researchers. This approach allows fast translation of discoveries from bench to bedside with improvement of patient care as ultimate goal.

In the current project we will explore the crosstalk between the mucosal immune system and the enteric nervous system. We have recently described that mediators released by the enteric nervous system are responsible for the tolerogenic imprinting of intestinal immune cells. This neuro-immune crosstalk seems to be crucial to preserve intestinal immune tolerance and prevent chronic inflammatory pathology of the gastrointestinal tract. Exploring these mechanisms hold great promise, not only for understanding how our organism operates in the healthy state, but also to develop novel therapeutic strategies to treat intestinal immune-mediated diseases such as inflammatory bowel disease, Coeliac disease or food allergy.



This project will involve a wide range of techniques including primary cell isolation, flow cytometry, molecular biology, microscopy and in vivo experiments.

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