Postdoctoral Fellow : Durham , NC, United States

Several postdoctoral and staff positions are available in the laboratory Dr. Jason Locasale. Dr. Locasale will be moving his research group to Duke University and positions are available beginning in September 2015. We are a group of young, energetic, and highly collaborative scientists consisting of biologists, computational scientists, and analytical chemists.

We are interesting in applying integrative approaches to understand metabolism and its contribution to health and disease. We are particularly interested in understanding the metabolism of cancers. We combine state-of-the-art mass spectrometry technology, stable isotope tracing for flux analysis, computational modeling, genomics, and rigorous biochemistry, cell biology, and physiology approaches. Under the direction of Dr. Jason Locasale (Duke Cancer Institute, Duke Molecular Physiology Institute, Professor of Pharmacology and Cancer Biology at Duke University Medical School), the postdoctoral fellow will be responsible designing and executing projects focused on metabolism.


Projects involving several areas of inquiry are available including: 1.) Understanding the influence of metabolism on chromatin biology. 2.) Computational modeling of metabolic regulation. 3.) Integrating cancer genomics and metabolomics data with biological validation for precision anti-metabolite therapy. 4.) Developing and applying tools for metabolomics and flux analysis. 5.) Understanding the biology of serine, glycine and one carbon metabolism in cancer.

The Scientist will also collaborate with other scientists at the Duke Cancer Institute and Duke Molecular Physiology Institute and have access to the numerous core facilities and resources. The person is expected to work independently to execute research projects. The person will gain training in grantsmanship through drafting fellowship proposals and assisting Dr. Locasale in annual grant reports to NIH, grant renewals, and other documents related to the project.