美国凯斯西楚大学蛋白质生物物理学/核磁共振博士后职位

How are signaling events transmitted from one protein to another; especially through the lipid bilayer? To answer these questions we are looking to add a postdoctoral co-worker to our interdisciplinary team. Our interest is to understand protein-protein interactions, protein structure and dynamics in the context of cell signaling mechanisms. {e.g. see our recent papers J.Biol.Chem. 286, 26093-106 (2011); Structure 20, 41-55 (2012), Cell Mol.Life Sci 69,3765-805 (2012); Proteins 81, 365-76 (2013); Biophys.J. 105, 2412-7 (2013); J.Biol.Chem. 289:19694-703 (2014)}. The systems include several small GTPases and their interacting proteins, principally the cytoplasmic and transmembrane domains of Plexins, Ephs and of other receptors.

Research in protein biophysics/structural biology. We principally use solution NMR for protein structure determination, surface mapping and characterization of conformational change. The project may involve NMR relaxation and molecular dynamics simulation as additional tools. NMR facilities at the Cleveland Center for Structural Biology consist of two 600MHz, an 800MHz and an 900MHz Bruker spectrometers all with cryoprobes. Apart from NMR, we employ other biophysical techniques including circular dichroism and fluorescence spectroscopy as well as ITC, SPR and Thermophoresis.

We are looking for a talented and highly motivated coworker, who aims to become an independent researcher/project leader. Prior experience with protein NMR is essential. The Buck laboratory provides a stimulating but friendly working environment. The Medical School of Case Western Reserve University is highly rated overall in the US (16th in terms of NIH funding) and Cleveland is a pleasant and affordable place to live with excellent educational, medical and cultural institutions. Starting date, project details and salary are negotiable.