录取机构：美国国立卫生研究院(National Institutes of Health，NIH)
Multiple postdoctoral positions are available in the laboratory of Dr. Jason Liu in the Department of Molecular Medicine at the University of Texas Health Science Center at San Antonio (UTHSCSA). Selected candidates will perform highly interdisciplinary and collaborative scientific research in one or more of the following areas: (1) Explore the function of signaling-regulated enhancers in breast and prostate cancers, and understand how enhancers are regulated by the crosstalk of different signaling pathways including sex hormones, inflammation signals and metabolic signals; (2) Decipher the epigenetic and 3D level changes of enhancers upon developmental/pathological stimuli or during hormone/drug resistance acquisition; (3) Based on our understanding of enhancer function mechanisms, identify diagnostic/prognostic biomarkers and therapeutic targets for multiple human cancer types; (4) Develop drugs and therapeutics for pre-clinical studies and potential clinical applications. Our research integrates next-generation sequencing (NGS)-based technologies and bioinformatics tools to investigate the component, epigenetic, and 3D level changes of enhancers in cancers (refer to Cell, 2014 159: 358–373). We are efficiently combining biochemical, cellular, and animal model-related studies with different NGS-based assays. Our research program will help the trainees from both wet and dry lab sides to build up strong expertise and training record in molecular biology and multi-omics (genomics, transcriptomics, proteomics, epigenomics and metabolomics). Positions require a Ph.D. degree (or equivalent) in biochemistry, cell biology, cancer biology, bioinformatics, or closely related biological sciences. The candidates need to have strong molecular biology background. Prior experience in patient-derived xenograft (PDX) models, breast/prostate cancer, and computational analyses is a strong plus.
One postdoctoral position is available in a cancer research lab located within the University of North Carolina Lineberger Cancer Center. The Pecot lab integrates use of bioinformatics, novel metastasis models and therapeutics to target metastatic biology. The project of interest will define how the immune microenvironment regulates lung squamous cancer metastasis. Our laboratory is funded by the American Cancer Society, University Cancer Research Fund Innovator Award, Jimmy V Scholar Foundation, Lung Cancer Initiative of North Carolina, NCI Cancer Center of Nanotechnology Excellence, the Lung Cancer Research Foundation and the Free to Breathe Metastasis Award. The Pecot lab is looking for eager, self-motivated scientists with excellent writing skills. Candidates with a strong background in tumor immunology and tumor microenvironment, extensive experience in FACS-based cell sorting, tissue culture, advanced cloning skills, RNA and protein techniques, and metastatic modeling are highly desired. The applicant must be comfortable working with laboratory mice, with a few years experience of handling mice preferred.
Postdoctoral positions available for tuberculosis research The Dr. Jianjun Sun’s laboratory of bacterial pathogenesis in the Department of Biological Sciences at the University of Texas at El Paso (UTEP) will have multiple postdoctoral positions starting as early as April of 2017. The primary research interest of Dr. Sun’s laboratory is to investigate the mechanisms of bacterial pathogenesis and recently focuses on Mycobacterium tuberculosis. Tuberculosis has been listed as a major infectious disease worldwide. We are investigating the basic cellular and molecular mechanisms of TB pathogenesis, and at the same time, we are developing novel therapeutic, preventive, diagnostic agents against TB. Dr. Sun’s laboratory is well funded by NIH and the lab is equipped with the state-of-the-art research instruments with the capability of performing the cutting-edge biomedical researches ranging from structural and functional characterization of macromolecules to operations of animal models. As a world-leading lab in the study of Mtb virulence factors, Dr. Sun’s group is highly productive and has an important impact in the research field. We are seeking highly motivated and dedicated young talents to join our research group. Individuals with a strong background in biochemistry, microbiology, cell and molecular biology are encouraged to apply. Candidates with backgrounds and experiences in protein chemistry and mycobacterial biology (e.g. Mycobacterium marinum and Mycobacterium tuberculosis) are highly preferred.
Postdoctoral position is immediately available in the laboratory of Dr. Ayako Makino at the University of Arizona. Area of research focuses on the vascular complication in diabetes, in particular cell-cell communication, mitochondrial function, and calcium handling in the endoplasmic reticulum in endothelial and smooth muscle cells. Successful candidate must have a Ph.D. in the biomedical sciences, M.D. or equivalent degree. A strong record of productivity in cardiovascular physiology (dissection of arterioles from mice, isometric tension measurement, evaluation of cardiac function [i.e., LVSP, RVSP, EF], and cell isolation) is required. The postdoctoral fellow's responsibilities will include: conducting physiological and molecular biological experiments using dissected vessels from mouse and vascular cells freshly isolated from the tissue, analyzing research data using different computer software, generation of preliminary data for grant applications, writing drafts of manuscripts, coordinating with other investigators for lab research, maintaining the function of lab equipment, and managing the lab research record (including methodological approaches and animal protocols).
Postdoctoral Researcher – cryo-Electron Tomography and Microscopy – fixed term – for up to 24 months The ISMB is seeking one Post-doctoral Research Assistant to carry out structural analysis of the Type IV Secretion System by cryo-electron tomography and cryo-electron microscopy with Professor Gabriel Waksman. The laboratory has been exceptionally productive over the years in this area (see Science, 2009, 323:266-268; Nature, 2009, 462:1011-1015; Nature. 2014, 508:550-3; and Cell. 2016, 166, 1436–1444). The research programme is funded by a grant from the Wellcome Trust. Applicants should have a PhD in Structural Molecular Biology, and experience in Electron Microscopy, Image Processing, Biophysics or related areas.
美国Janssen Research & Development神经系统科学博后职位招聘
Janssen Research & Development, L.L.C., a Johnson & Johnson company, is recruiting for a postdoctoral fellow for the Neuroscience Discovery group, located in La Jolla, CA. Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neuropsychiatry neurologic disorders, oncology, infectious disease, metabolic disorders and immunologic disorders. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners, from clinics to hospitals. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion, Janssen Research & Development, LLC is proud to be an equal-opportunity employer. We are seeking a highly motivated neuroimmunologist to join the Neuroscience Discovery research team, devoted to the discovery and development of novel therapeutics for neurological and neuropsychiatric disorders. The successful candidate must be well-versed in immunology and have experience working with CNS models. She/he will undertake challenging scientific questions in the area of neuro-immune interactions, with specific focus on the borders of the brain, i.e. meninges, choroid plexus, blood-brain barrier. A proven background in adaptive and particularly humoral immunity is required for the position. The candidate must demonstrate unconventional scientific curiosity, intellectual hunger, be innovative, and be self-driven to take on challenging projects. A desire to complete projects within a specific timeframe of 2-3 years is a must. Postdoctoral fellows are highly encouraged to publish their science in top tier journals with high impact factor.
A postdoctoral position is available immediately in the Department of Genetics, Genomics and Informatics at University of Tennessee Health Science Center, Memphis, Tennessee The successful applicant will work with an interdisciplinary team of investigators with expertise in cardiovascular disease, neurodegenerative disease, metabolic disease, anxiety or other mental disorder, glaucoma, and mouse genetics. Requirements include a Ph.D. or M.D., a strong record of research accomplishments and productivity, and research experience in at least one of the following areas: (1) Mouse and/or human genetics: experience with QTL, GWAS, and statistical genetics (2) bioinformatics or system biology: experience working with different types of high throughput data such as microarray, RNA-seq, and ChIP-seq; (3) genetics of cardiovascular disease: experience with cardiomyopathy research in particular; (4) Molecular biology: experience with gene cloning and loss-of-function technique.
The position focus on the study of the role of macrophages in tissue repair. The laboratory uses a combination of flow cytometry analysis, RNAseq, immunofluorescence and in vitro assays to characterize macrophage subpopulations involved in the rescue of degenerative tissues after transplantation of hematopoietic stem cells in murine models of genetic disorders.The candidate should be highly self-motivated, with strong communication and interpersonal skills and have the ability to work independently, has a PhD, with a strong background in immunology, cell and molecular biology. Experience with mice, FACS and/or RNAseq are preferred.
Expressions of interest are sought from outstanding researchers for a Post-doctoral position in bioinformatics and systems biology in the Viral Immunology Systems Program (VISP) at the Kirby Institute within the University of New South Wales, Sydney, Australia. Working in close collaboration with both wet and dry members of the VISP group to perform bioinformatics and systems biology analyses in single cell genomics and other data sets, this position will focus on the development and application of bioinformatics and machine learning approaches for analyzing and interpreting single cell transcriptomics data, flow cytometry data, and next generation sequencing data of viral genomes to study immune responses against viral infections, such as HCV, influenza, and other human pathogens. The position is also co-affiliated with the UNSW School of Medical Sciences. There is also a strong collaborative link with the Weizmann Garvan Institute for Cell Genomics, and several collaborations nationally and internationally. Required Skills and Experience • PhD in computational biology, mathematics, biostatistics or related fields • Highly developed skills in bioinformatics and/or computational biology • Experience in Genomics and/or transcriptomics analyses • Good knowledge and skills in languages, such as R, Python, C++ • Evidence of publications in influential, high-impact journals • Strong communication skills and the ability to work as part of a team
We are currently seeking a highly-motivated postdoctoral scientist to work with Prof Eoin Scanlan on a collaborative, multidisciplinary Chemical Protein Synthesis project funded by Science Foundation Ireland. The successful candidate will be employed by Trinity College and the position will be located in the state-of-the-art Trinity Biomedical Sciences Institute which has excellent, newly constructed facilities for synthetic organic chemistry and drug discovery. The aim of the project is to develop and optimise a novel synthetic methodology for peptide ligation/protein modification and to apply this methodology to the synthesis of therapeutic proteins with defined post-translational modifications. The work will involve peptide synthesis, methodology development, purification and in vitro analysis of synthetic proteins. You should have a PhD with a strong background in one or more of the following areas: synthetic organic chemistry (ideally, working with peptides but training will be provided), methodology development, chemical biology, protein purification/modification.
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