录取机构：美国国立卫生研究院(National Institutes of Health，NIH)
Postdoctoral Researcher : Norwich, United Kingdom Postdoctoral Researcher We have an opportunity for an outstanding post-doctoral scientist within the Patron Group at the Earlham Institute (EI) to work on a collaborative project with the O'Connor group at the John Innes Centre (JIC). The candidate must have a comprehensive understanding of methods used in heterologous gene expression, a good understanding of plant secondary metabolism and laboratory skills in molecular biology and biochemistry. The project aims to improve heterologous plant production chassis and to contribute to our understanding of how the rich endogenous metabolism of plants detoxifies foreign molecules. Specifically, the post holder will use RNA-guided Cas9 and virus-induced gene silencing to introduce mutations and downregulate endogenous genes predicted to interfere with or prevent heterologous expression of proteins and metabolites. This will pave the way for more effective plant production chassis for efficient production of proteins and small molecules, including vaccines and human therapies. The post-holder will contribute to the selection of gene targets, construct design and assembly, genotyping, heterologous expression, and quantification of heterologously expressed proteins and metabolites. Technical assistance will be provided for the generation of genome-engineered plants and the post-holder will have access to the cutting-edge laboratory automation facilities at EI's DNA Foundry. The post-holder will also interact with stakeholders at LeafSystems® and have the opportunity to work and collaborate with scientists in the OpenPlant Synthetic Biology Research Centre. The successful applicant will have a PhD in Molecular Biology, Biochemistry, Biological Chemistry, Plant Biology, Synthetic Biology, or a related subject. Experience in molecular cloning, genotyping and expression analyses are all essential, and experience with LC- and GC-based mass spectrometry metabolomics are desirable.
Postdoctoral fellow : Philadelphia, PA, United States Post Doctoral Fellows – Department of Neurology Two post doctoral positions are available at the Neuroimmunology Laboratory in the Department of Neurology, Thomas Jefferson University. The research projects focus on mechanism and immunotherapy for the animal model of Multiple Sclerosis. We are seeking highly motivated researchers who have recently completed their doctoral programs. Requirements include background in immunology / T cell biology. Experience in autoimmunity and molecular biology is highly desirable.
Postdoctoral Research Fellow position in the Molecular Oncology Department and Cancer Biology and Evolution Program : Tampa, FL, United States ostdoctoral Research Fellow position in the Molecular Oncology Department and Cancer Biology and Evolution Program at Moffitt Cancer Center, Tampa, FL, United States. The laboratory of Dr. Michael B. Mann seeks a highly motivated, independent, and collaborative postdoctoral research fellow interested in conducting exciting inter-disciplinary research aimed at discovering and functionally testing the genetic and epigenetic drivers of skin cancer initiation, progression, and therapeutic resistance. We seek an individual with a recent doctoral degree (completed within the last 3 years) in cancer biology, molecular biology, genetics, or related discipline and a strong publication record. Applicants should be able to demonstrate understanding and practice of fundamental research methodologies, including how to plan and conduct experiments and evaluate and report research findings. Experience in basic molecular biology techniques, including cloning, PCR, nucleic acid and protein extraction and manipulation, culturing mammalian cell lines is preferred. Exceptional candidates will also have experience building libraries for next generation sequencing and/or working with translational rodent models of human disease. Applicants are expected to have a working knowledge of Microsoft Office software, including Powerpoint and Excel, and a willingness to learn and become proficient in the use of biomedical research-oriented computer language(s) and database(s). Successful candidates must be dedicated to full-time research and possess excellent organizational skills and excellent verbal and written communication skills. Trainees will develop experimental expertise in molecular oncology, cancer genomics, and preclinical animal modeling and will be mentored in project management, experimental design, and scientific communication. Trainees will have opportunities to work with an interdisciplinary core team comprised of cancer geneticists, computational biologists, and biostatisticians, and to collaborate with clinical partners to develop and test translational application(s) of research findings. You will join a team of dynamic research professionals dedicated to the mission of contributing to the prevention and cure for cancer.
Postdoctoral position in Chemical and Structural Biology of RNA : Jupiter, FL, United States A postdoctoral position in RNA chemical biology is available in the Disney group in the Department of Chemistry at The Scripps Research Institute. Successful candidates will have a proven track record of publishing in high impact journals and expertise in organic synthesis, nucleic acids, medicinal chemistry, or chemical biology. S/he must be able to work as a member of a team. The specific focus of the position is on the rational design of small molecules that target RNA for use as both lead therapeutics and chemical probes of function. In particular, the approach will be applied toward diseases that have no known therapeutic or to which there is poor prognosis with current treatments including inherited neuromuscular diseases such as ALS and muscular dystrophy or highly resistant cancers.
Postdoctoral Opportunity in RNA and Cancer Biology : New Haven, CT, United States A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence suggests an involvement in a broad range of biological processes and in human disease, including cancer. We select candidates based on their regulation by key oncogenes and tumor suppressors or based on their involvement in cancer processes, such as the DNA damage response, oncogenic transformation, and metastasis. Our goal is to understand how candidate lncRNAs contribute to oncogenic and tumor suppressive networks at the molecular, cellular, and organismal level and how deregulation of lncRNAs leads to cellular transformation and tumor development. At the molecular level, we aim to elucidate the diverse mechanisms by which cis- and trans-regulatory lncRNAs fine-tune oncogenic and tumor suppressive networks by modulating transcriptional and translational pathways. At the cellular level, we aim to understand how lncRNAs participate in the decision-making processes in complex transcriptional networks and what are the consequences of lncRNA activity for cellular homeostasis and stress response. Finally, to bring insights into the vastly understudied contribution of lncRNAs to tumorigenesis in vivo, we are testing how inappropriate expression of regulatory lncRNAs influences tumor development in mouse models of lung adenocarcinoma. A successful candidate will hold a Ph.D. degree, will be highly motivated to perform cutting edge research and to interact with a dynamic, young group of investigators. Candidates from diverse scientific backgrounds are strongly encouraged to apply.
Postdoctoral/Graduate Student Positions - Medical Genetics : Edmonton, Canada University of Alberta Postdoctoral/Graduate Student Positions The laboratory of Dr. Toshifumi Yokota invites applications for postdoctoral and graduate student positions in the Department of Medical Genetics at the University of Alberta. By utilizing integrative experimental and computational approaches, such as antisense oligonucleotides and CRISPR/Cas9, the focuses of our group are to develop novel molecular therapies for neuromuscular diseases and rare genetic diseases. Our group is actively collaborating with the world-class researchers and industry partners. The highly interdisciplinary and collaborative environment of our research group provides unique career development opportunities for the postdoctoral trainees and graduate students. The program is run by Dr. Toshifumi Yokota, Assistant Professor and the Muscular Dystrophy Canada Research Chair. His laboratory is renowned internationally for its work on the development of exon skipping/antisense technology as well as the study on animal models. The CIHR Program will focus on advancing novel therapies for genetic diseases.
Postdoctoral Researcher (Mechanisms of Brain-Gut Interaction) : Wako-shi, Saitama, Japan RIKEN Brain Science Institute (BSI) is located in Wako-shi, Saitama, just outside of Tokyo in Japan. As part of BSI, our group – Laboratory for Symbolic Cognitive Development (Laboratory Head: Atsushi Iriki ) – tries to uncover evolutionary precursors of human higher cognitive functions connected to physical morphologies and patterns of structured bodily actions. These are investigated using behavioral and neurophysiological analyses on primates, which were trained to use tools and other apparatus. Postdoctoral position / Scientist in microbiome analysis The Laboratory for Symbolic Cognitive Development (SCD) seeks a talented and highly motivated scientist to pursue the divergence of primate cognitive abilities from the perspective of the brain-gut interaction. This research will be conducted under the framework of the collaborative research project: “Primate model of “Mind-Body Interaction” through the mechanisms of gut-brain axis via microbiome.” This project is supported by the Canadian Institute for Advanced Research’s (CIFAR) Catalyst Projects to establish cross-disciplinary collaborations between the Azrieli Program in Brain, Mind & Consciousness and the program on Humans & the Microbiome . CIFAR brings together outstanding researchers to work in global networks that address some of the most important questions our world faces today. The research is focused on improving human health, transforming technology, building strong societies, and sustaining the Earth. Established in 1982, CIFAR is comprised of nearly 400 fellows, scholars and advisers from more than 130 institutions in 16 countries. This research project is a collaboration between Professors Atsushi Iriki at RIKEN BSI and Sven Pettersson at Nanyang Technological University (NTU) inSingapore, and is a part of the RIKEN-NTU Collaboration Research Center, newly launched in January 2017. Thus, this is a co-mentored position, such that the applicant can seek guidance from both professors.
Bioinformatician on Immunology: Osaka, Japan : Osaka, Japan KOTAI Biotechnologies, Inc. (KOTAI, Osaka, Japan) is a bioinformatics spinoff from Osaka University's world leading research center, Immunology Frontier Research Center (IFReC) launched in 2016. Their unique and sophisticated bioinformatics has enabled to analyze high throughput immune repertoire (BCR, TCR, antibodies, etc) data in higher resolution than ever before. Since an immune repertoire shows the fingerprints of our past and current biological states, it is highly expected to detect signals of various kinds of diseases such as infectious and autoimmune diseases and cancer. In collaboration with pharmaceutical and biotechnology companies as well as academic institutions, KOTAI would work on discoveries of new biomarkers and therapeutic compounds through the repertoire analysis. We recruit two bioinformatics researchers for immune repertoire analysis, the algorithm development, and structural bioinformatics on Immunology. Since both the immune-sequencing and our bioinformatics approach is new, there are huge opportunities to invent new therapeutics. To this end, we need to develop and improve our bioinformatics algorithms by integrations of different experimental data types and approaches for the data analysis. We welcome researchers who are eager to develop new algorithms, work on new data with experimentalists and contribute to the society by developing new therapies. Since individuals of the company should work with people with different backgrounds, they have to be team players and good communicators.
Postdoctoral Positions In Atomistic Simulations Of Advanced Materials : Prague, Czech Republic Applications are invited for postdoctoral researchers in the Advanced Materials Group (AMG) at the Faculty of Electrical Engineering, Czech Technical University in Prague, to work on atomistic simulations of advanced materials, under the supervision of Prof. Tomas Polcar. AMG is a well-established group and consists of dynamic and motivated researchers leading international collaborations on broad interdisciplinary topics. Research areas include the in silico design of smart self-assembling materials (e.g. carbon nanotubes, solid state perovskites and transition metal dichalcogenide heterostructures) for photovoltaic applications, combining theoretical approaches represented by advance nanoscale simulations and the exploration of the complex impact of photovoltaics on urban systems and architecture. Work will focus on the design of optically active centers (OAC) able to convert incoming photons into free electrons, as well as the study of the self-assembling processes occurring between the OAC, the conductive matrix and the substrate. Another available topic will concentrate on the interaction between helium and multilayer composite materials, ultimately determining the role of interfaces in He trapping and self-healing phenomena, providing useful information for nanoscale material design. Work will consist of screening preferential sites where He atoms settle in proximity of a bimetallic interface, studying the energetics of He atom diffusion near to and across the interface, and investigating mechanisms of nucleation and growth of He bubbles in close proximity to the interface.
PhD in Photonics at the Optoelectronics Research Centre, University of Southampton Working alongside some of the world’s leading photonics scientists, you will spend your time conducting novel research in our state-of-the-art optical laboratories and clean room facilities, keeping up-to-date with current research trends in photonics, writing journal papers and attending conferences. Our extensive training programme provides thorough grounding for your PhD and future career through specialist photonics lectures and demonstrations, and skills training in report writing and presenting. We also offer plenty of opportunities for networking with fellow researchers and potential employers through attendance at national and international conferences, as well as internal industry and academic events. World-leading research You can study an individual project within one of our 30 research groups covering: • Fundamental photonics • Light generation and manipulation • Nanophotonics and metamaterials • Optical biosensors and biophotonics • Optical fibres • Optical materials • Optical networks and systems • Silicon Photonics • Sensing The ORC is one of the world’s leading institutes for photonics research based at the University of Southampton. We have a vibrant community of researchers, led by some of the leading figures in the field of photonics. We have contributed significantly to the remarkable growth of the photonics industry, including the optical telecommunication technology that underpins the internet as well as many solutions in medicine, biosciences sensing, security and manufacturing.
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